Afatinib Impurity 23 CAS CATO-C4X-100623
| CAS No. | CATO-C4X-100623 |
| Molecular Formula | C28H29ClFN5O7 |
| Molecular Weight | 602.01 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Afatinib Impurity 23 (CAS CATO-C4X-100623, C28H29ClFN5O7) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Afatinib Impurity 23 (C28H29ClFN5O7) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Afatinib Impurity 23 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C28H29ClFN5O7 |
| Molecular Weight | 602.01 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 5 |
Related Afatinib Standards
- Afatinib Impurity 95 (CAS CATO-C4X-100695)
- Afatinib Impurity 67 (CAS CATO-C4X-100667)
- Afatinib Impurity 59 (CAS 618061-77-1)
- Afatinib Impurity 26 (CAS CATO-C4X-100626)
- Afatinib Impurity 48 (CAS 3005278-77-0)
- Afatinib Impurity 8 (CAS CATO-C4X-10068)
- Afatinib Impurity 33 (CAS CATO-C4X-100633)
- Afatinib Impurity 47 (CAS CATO-C4X-100647)
Recommended Standards
- 1,3-17:0 D5DG (CAS 1246523-65-8)
- Triundecanoin-d5 (CAS CATO-C4X-217150)
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- Iohexol Impurity 52 (CAS CATO-C4X-166452)
- Amoxicillin Impurity 85(Mixture) (CAS CATO-C4X-114885)
- Urapidil Impurity 52 (CAS 5770-45-6)
- Piperacillin EP Impurity R (CAS CATO-C4X-173225)
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- Methyl 6-amino-5-cyano-2-(((3-cyano-4,6-dimethylpyridin-2-yl)thio)methyl)-4-(pyridin-3-yl)-4H-pyran-3-carboxylate (CAS 354554-90-8)
- 1. 1-(((2R, 3S)-2-(2,4-difluorophenyl)-3-Methyloxiran-2-yl) Methyl)-1H-1,2,4-triazole (CAS 127000-90-2)
- Ethyl 2-amino-6-(2-hydroxyphenyl)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (CAS 914202-54-3)
- 3-Mesityl-6,7,8,9-tetrahydrocycloocta[d]isoxazole (CAS 88415-47-8)
- 1332530-39-8 N-[(2-Isopropylpyrimidin-4-yl)methyl]ethanamine dihydrochloride MFCD18071398 (CAS 1332530-39-8)
- Semaglutide Impurity 137 (x TFA Salt) (CAS CATO-C4X-2226137)
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