Clemastine Impurity 7 Fumarate (R,S-isomer) CAS 61826-30-0
| CAS No. | 61826-30-0 |
| Molecular Formula | C21H26ClNO |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 459.97 g/mol gives Clemastine Impurity 7 Fumarate (R,S-isomer) distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Clemastine Impurity 7 Fumarate (R,S-isomer) (CAS 61826-30-0), a pharmacopoeial impurity reference standard (molecular formula C21H26ClNOC4H4O4, MW 459.97 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Clemastine Impurity 7 Fumarate (R,S-isomer) (C21H26ClNOC4H4O4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 11.0, corresponding to approximately 11 ring(s) or double-bond equivalent(s). With a molecular weight of 459.97 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H26ClNO C4H4O4 |
| Molecular Weight | 459.97 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1974 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Clemastine Standards
- Clemastine Impurity 27 (CAS 10095-17-7)
- Clemastine EP Impurity A(Mixture of Diastereomers) (CAS 108825-05-4)
- Clemastine Impurity 28 (CAS 1333340-87-6)
- Clemastine EP Impurity B (CAS 1352549-49-5)
- Clemastine fumarate (CAS 14976-57-9)
- Clemastine (CAS 15686-51-8)
- Clemastine Impurity 26 (CAS 171296-35-8)
- Clemastine Impurity 4 (CAS 20763-27-3)
Recommended Standards
- Palonosetron Impurity 35 (CAS CATO-C4X-110535)
- Decitabine Impurity 33 (CAS CATO-C4X-113733)
- Oxcarbazepine EP Impurity A (Carbamazepine) (CAS 298-46-4)
- tert-Butyl 3-hydroxy-1-oxa-7-azaspiro[3.5]nonane-7-carboxylate (CAS 1638759-42-8)
- 4-(Aminomethyl)-N,N-dimethylaniline (CAS 19293-58-4)
- 9,10-Di(1H-pyrazol-4-yl)anthracene (CAS 2230684-04-3)
- 1-(2,4-Dichloro-5-methoxyphenyl)-1,2-dihydro-5H-tetrazole-5-thione (CAS 400085-60-1)
- 2,6-Bis-(1-phenylethyl)phenol (CAS 4237-28-9)
- 4-Chloro-6-(4-chlorophenyl)-2-(1-methoxyethyl)pyrimidine (CAS 1708437-46-0)
- Tau Peptide (45-73) (Exon 2/Insert 1 Domain) trifluoroacetate salt (CAS 2022956-54-1)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com