4'-(Trifluoromethoxy)biphenyl-3-carboxylic acid CAS 728919-12-8
| CAS No. | 728919-12-8 |
| Molecular Formula | C14H9F3O3 |
| Molecular Weight | 282.21 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
4'-(Trifluoromethoxy)biphenyl-3-carboxylic acid (CAS 728919-12-8) is a high-purity analytical reference standard with the molecular formula C14H9F3O3 and a molecular weight of 282.21 g/mol.
The molecular framework of 4'-(Trifluoromethoxy)biphenyl-3-carboxylic acid (C14H9F3O3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, a polycyclic aromatic system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 4'-(Trifluoromethoxy)biphenyl-3-carboxylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H9F3O3 |
| Molecular Weight | 282.21 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | F-containing |
Related Trifluoromethoxy Standards
- 3'-(Trifluoromethoxy)biphenyl-3-carboxylic acid (CAS 1215206-30-6)
- 4-(4-(Trifluoromethoxy)phenoxy)benzaldehyde (CAS 137736-08-4)
- 2'-(Trifluoromethoxy)biphenyl-3-carboxylic acid (CAS 765276-04-8)
- 4'-(Trifluoromethoxy)-[1,1'-biphenyl]-2-carboxylic acid (CAS 408366-18-7)
- 4-(Trifluoromethoxy)-[1,1'-biphenyl]-2-carboxylic acid (CAS 2379321-48-7)
- 4-[2-(Trifluoromethoxy)phenyl]benzoic acid (CAS 926220-09-9)
- (4-(4-(Trifluoromethoxy)benzyl)phenyl)methanol (CAS 1263417-30-6)
- {4-[4-(Trifluoromethoxy)phenyl]phenyl}boronic acid (CAS 501944-50-9)
Recommended Standards
- 4-[3-(Trifluoromethyl)phenoxy]benzoic acid (CAS 632366-11-1)
- 4-(4-Trifluoromethoxyphenyl)benzoic acid (CAS 728919-11-7)
- 4-Hydroxy-2'-(trifluoromethyl)-[1,1'-biphenyl]-3-carboxylic acid (CAS 400744-89-0)
- 4-(4-(Trifluoromethyl)phenoxy)benzoic acid (CAS 78161-82-7)
- Methyl 1-chloroisoquinoline-7-carboxylate (CAS 1206975-02-1)
- 4-(4-Cyclopropylpiperazin-1-yl)-6-methylpyrimidin-2-amine (CAS 1026721-45-8)
- Synaptamide-d (CAS 946524-43-2)
- Ethyl 5-amino-4-carbamoyl-1H-pyrazole-1-carboxylate (CAS 220131-62-4)
- 5-Acetyl-3-((4-fluorophenyl)thio)-4-methyl-2H-[1,2'-bipyridin]-2-one (CAS 918542-91-3)
- N-(6-Amino-3-methyl-2,4-dioxo-1-phenyl-1,2,3,4-tetrahydropyrimidin-5-yl)-3,5-dibutyl-4-hydroxybenzamide (CAS 176370-44-8)
- 4-(1h-Indazol-1-yl)benzoic acid (CAS 838820-85-2)
- 5-(Trifluoromethoxy)quinolin-4-ol (CAS 1261749-07-8)
- 1-Bromo-2,3,4-trimethoxybenzene (CAS 10385-36-1)
- Neuropeptide Y (13-36) (porcine) (CAS 113662-54-7)
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