Berberine Hydrochloride CAS 633-65-8
| CAS No. | 633-65-8 |
| Molecular Formula | C20H18NO4 |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Berberine Hydrochloride (CAS 633-65-8), a certified reference material (molecular formula C20H18NO4Cl, MW 371.82 g/mol) for analytical method development and quality control.
The molecular framework of Berberine Hydrochloride (C20H18NO4Cl) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), Berberine Hydrochloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C20H18NO4 Cl |
| Molecular Weight | 371.82 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Berberine Standards
- Berberine Impurity 33 (CAS 100101-07-3)
- Berberine Impurity 15 Chloride (CAS 1186107-72-1)
- Berberine Chloride hydrate (CAS 141433-60-5)
- Berberine Impurity 31 (CAS 17388-19-1)
- Berberine Impurity 14 (CAS 2043361-62-0)
- Berberine (CAS 2086-83-1)
- Berberine Impurity 16 Chloride (CAS 2363741-22-2)
- Berberine Impurity 29 (CAS 2375597-30-9)
Recommended Standards
- 3-Benzyl-3,9-diaza-bicyclo[3.3.1]nonane dihydrochloride (CAS 93865-26-0)
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- 1-Bromoethanol (CAS 162854-32-2)
- N-(1-Cyanocyclopentyl)-2-(methyl(4-(methylthio)benzyl)amino)acetamide (CAS 850021-45-3)
- 1-Ethyl-4,5,6-trimethoxy-1h-indole-2-carboxylic acid (CAS 1240578-66-8)
- N-Cbz-glycine Ethyl Ester (CAS 1145-81-9)
- 2-(Butoxymethyl)benzenethiol (CAS 1378574-70-9)
- 1-(2,3-Dihydro-1H-inden-5-ylsulfonyl)-piperidin-4-one (CAS 1152584-61-6)
- 3-amino-2-[(3-bromo-4-methoxyphenyl)methyl]propan-1-ol hydrochloride (CAS 1909312-39-5)
- Neuropeptide Y (13-36) (human, rat) (CAS 122341-40-6)
Why CATO?
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