4-Chloro-5-iodopyrimidine CAS 63558-65-6
| CAS No. | 63558-65-6 |
| Molecular Formula | C4H2ClIN2 |
| Molecular Weight | 240.43 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), 4-Chloro-5-iodopyrimidine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
4-Chloro-5-iodopyrimidine (CAS 63558-65-6) is a high-purity analytical reference standard with the molecular formula C4H2ClIN2 and a molecular weight of 240.43 g/mol.
The molecular framework of 4-Chloro-5-iodopyrimidine (C4H2ClIN2) is characterized by a nitrile group, chlorine/iodine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C4H2ClIN2 |
| Molecular Weight | 240.43 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1975 |
| Halogen Content | Cl/I-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
- 2-Chloro-5-iodopyrazine (CAS 1057216-55-3)
- 4-Chloro-2-iodopyrimidine (CAS 1108165-28-1)
- 2-Chloro-6-iodopyrazine (CAS 120531-35-3)
- 5-Chloro-4-iodopyrimidine (CAS 1261473-90-8)
- 5-Chloro-3-iodopyridazine (CAS 1616070-38-2)
- 2-Chloro-3-iodopyrazine (CAS 191340-85-9)
- 2-Chloro-4-iodopyrimidine (CAS 395082-55-0)
- 2-Chloro-5-iodopyrimidine (CAS 32779-38-7)
Recommended Standards
- EBDC-Dimethyl (CAS 20721-48-6)
- Thiram (CAS 137-26-8)
- 1-Undecylpiperazine (CAS 82394-26-1)
- 3-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]benzenethiol (CAS 216393-56-5)
- 5-Methyl-5-(Sulfanylmethyl)imidazolidine-2,4-dione (CAS 655249-41-5)
- 5-[(3-ethoxypropyl)amino]-1,3,4-thiadiazole-2-thiol (CAS 871548-19-5)
- 1-(2-Methoxyethyl)cyclobutane-1-carbonitrile (CAS 1394041-18-9)
- 4-(4-Chlorophenyl)-1-(3-nitrophenyl)-1H-pyrazol-5-amine (CAS 324008-90-4)
- 4-(5-Chloro-1H-benzo[d]imidazol-2-yl)aniline (CAS 39861-21-7)
- 3-Benzyl-7-ethyl-2-mercapto-5,6,7,8-tetrahydro-3H-9-thia-1,3,7-triaza-fluoren-4-one (CAS 352446-15-2)
- Boc-2-amino-4-thiazole Acetic Acid (CAS 89336-46-9)
- CAS CATO-C4X-34243 (CAS CATO-C4X-34243)
- 7-Hydroxy-4-(4-methoxyphenyl)-8-methyl-2h-chromen-2-one (CAS 370583-62-3)
- Semaglutide impurity 233 (CAS CATO-C4X-2226233)
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