Apremilast Impurity 2 CAS 635705-72-5
| CAS No. | 635705-72-5 |
| Molecular Formula | C20H22N2O6S |
| Molecular Weight | 418.46 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Apremilast Impurity 2 (CAS 635705-72-5, C20H22N2O6S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Apremilast Impurity 2 (C20H22N2O6S) is characterized by a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H22N2O6S |
| Molecular Weight | 418.46 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Apremilast Standards
- Apremilast impurity 18 (CAS 1384439-79-5)
- Apremilast Impurity 117 (CAS CATO-C4X-1009117)
- Apremilast Impurity 37 (CAS 1407140-51-5)
- Apremilast Impurity 26 (CAS CATO-C4X-100926)
- Apremilast impurity 17 (CAS CATO-C4X-100917)
- Apremilast impurity 63 (CAS 1384967-20-7)
- Apremilast impurity 19 (CAS 1384440-16-7)
- Apremilast Impurity 35 (CAS 253168-83-1)
Recommended Standards
- N-benzyl-3-(thiophen-2-yl)-6-(trifluoromethyl)thieno[3,2-b]pyridine-2-carboxamide (CAS 477845-21-9)
- Pitavastatin Impurity 108 (CAS CATO-C4X-1037108)
- N-(4-Methoxy-3-(2-oxopiperidin-1-yl)phenyl)-2,3-dihydrobenzo[b][1,4]dioxine-6-sulfonamide (CAS 941893-71-6)
- Beraprost Impurity 25 (CAS CATO-C4X-218425)
- Opicapone Impurity 87 (CAS CATO-C4X-240487)
- Apixaban Impurity 36 (CAS 85014-68-2/2228050-22-2)
- Midecamycin Impurity 27 (CAS CATO-C4X-312227)
- N-[2-(2-Ethoxyethoxy)benzyl]-3-(2-methoxyethoxy)aniline (CAS 1040686-67-6)
- (3β,20R)-Pregn-5-ene-3,17,20-triol (CAS 2204-13-9)
- 5-(2-Fluorobenzoyl)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one (CAS 866138-21-8)
- p-Bromofluorobenzene-d4 (CAS 50592-31-9)
- 4-(Aminomethyl)-5-ethylfuran-2-carboxylic acid (CAS 844882-35-5)
- 5-(4,5-Dimethoxy-2-methylphenyl)-1,3,4-oxadiazol-2-amine (CAS 62035-98-7)
- D-Ser39-Tirzepatide (CAS CATO-CPTD788679)
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