2-Chloro-6-(4-(trifluoromethyl)phenyl)pyrazine CAS 637352-84-2
| CAS No. | 637352-84-2 |
| Molecular Formula | C11H6ClF3N2 |
| Molecular Weight | 258.63 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-Chloro-6-(4-(trifluoromethyl)phenyl)pyrazine (CAS 637352-84-2), molecular formula C11H6ClF3N2 and molecular weight 258.63 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution, 2-Chloro-6-(4-(trifluoromethyl)phenyl)pyrazine is typically pale yellow to yellow low-melting solid. Its solid-state physicochemical attributes — including a molecular weight of 258.63 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-Chloro-6-(4-(trifluoromethyl)phenyl)pyrazine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H6ClF3N2 |
| Molecular Weight | 258.63 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
- 3-Chloro-2-(pyridin-3-yl)-5-(trifluoromethyl)pyridine (CAS 1214324-38-5)
- 2-Chloro-3-(pyridin-3-yl)-6-(trifluoromethyl)pyridine (CAS 1214347-45-1)
- 2-Chloro-3-(pyridin-4-yl)-6-(trifluoromethyl)pyridine (CAS 1214355-04-0)
- 3-Chloro-2-(pyridin-3-yl)-6-(trifluoromethyl)pyridine (CAS 1214356-58-7)
- 3-Chloro-2-(pyridin-4-yl)-6-(trifluoromethyl)pyridine (CAS 1214366-95-6)
- 2-Chloro-3-(pyridin-4-yl)-5-(trifluoromethyl)pyridine (CAS 1214366-98-9)
- 3-Chloro-2-(pyridin-4-yl)-5-(trifluoromethyl)pyridine (CAS 1214370-11-2)
- 2-Chloro-3-(pyridin-3-yl)-5-(trifluoromethyl)pyridine (CAS 1214370-14-5)
Recommended Standards
- 2-Chloro-5-(4-(trifluoromethyl)phenyl)pyrimidine (CAS 75175-40-5)
- 3-Chloro-6-(4-(trifluoromethyl)phenyl)pyridazine (CAS 66548-88-7)
- 2-Chloro-5-(3-(trifluoromethyl)phenyl)pyrimidine (CAS 75175-42-7)
- 3-Chloro-6-[3-(trifluoromethyl)phenyl]pyridazine (CAS 66548-63-8)
- 2-Chloro-2-(hydroxyimino)acetic Acid Methyl Ester (CAS 30673-27-9)
- 2-(5-Amino-1-methyl-3-(pyridin-4-yl)-1H-pyrazol-4-yl)acetic acid (CAS 1708380-19-1)
- 4-Ethynyl-2-fluoro-1-(trifluoromethyl)benzene (CAS 1696971-45-5)
- 2'-Formyl-5-hydroxy-[1,1'-biphenyl]-3-carbonitrile (CAS 1261931-41-2)
- Edoxaban Impurity 59 (p-Toluenesulfonic acid) (CAS 2852734-45-1)
- Sildenafil Impurity 306 (CAS CATO-C4X-1128306)
- tert-butyl N-amino-N-(3-thienyl)carbamate (CAS 91538-51-1)
- (S)-1-(tert-Butoxycarbonyl)-2-(prop-2-yn-1-yl)pyrrolidine-2-carboxylic acid (CAS 1217671-12-9)
- 4,6-Dimethylpicolinic acid (CAS 18088-10-3)
- Semaglutide Impurity 187 (CAS CATO-C4X-2226187)
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