1-(Difluoromethyl)-2-fluorobenzene CAS 63878-70-6
| CAS No. | 63878-70-6 |
| Molecular Formula | C7H5F3 |
| Molecular Weight | 146.11 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
1-(Difluoromethyl)-2-fluorobenzene (CAS 63878-70-6), molecular formula C7H5F3 and molecular weight 146.11 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to fluorine substitution, an aromatic ring system, 1-(Difluoromethyl)-2-fluorobenzene is typically off-white to pale yellow liquid. Its solid-state physicochemical attributes — including a molecular weight of 146.11 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), 1-(Difluoromethyl)-2-fluorobenzene meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H5F3 |
| Molecular Weight | 146.11 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1975 |
| Halogen Content | F-containing |
Related Difluoromethyl Standards
- 1-(Difluoromethyl)-3-fluorobenzene (CAS 26029-52-7)
- 1-(Difluoromethyl)-4-fluorobenzene (CAS 26132-51-4)
- 2-(Difluoromethyl)pyrimidin-5-ol (CAS 100991-19-3)
- 1-(Difluoromethyl)-1H-pyrazole-4-carbaldehyde (CAS 1216244-84-6)
- 1-(Difluoromethyl)-1h-imidazole-2-carbaldehyde (CAS 1248811-92-8)
- 6-(Difluoromethyl)pyrazin-2(1H)-one (CAS 1261630-68-5)
- 6-(Difluoromethyl)pyrimidin-4(3H)-one (CAS 126538-89-4)
- 1-(Difluoromethyl)-1H-pyrazole-3-carbaldehyde (CAS 1432681-54-3)
Recommended Standards
- 1,3-Difluoro-5-(fluoromethyl)benzene (CAS 170646-72-7)
- 1,2,5-Trifluoro-3-methylbenzene (CAS 132992-29-1)
- 1,2,4-Trifluoro-3-methylbenzene (CAS 119916-25-5)
- 1,2,3-Trifluoro-5-methylbenzene (CAS 284463-96-3)
- 3-Fluoro-4-methanesulfonamidobenzene-1-sulfonyl chloride (CAS 1016704-20-3)
- {4-[5-(Thiophen-2-yl)-1,2,4-oxadiazol-3-yl]phenyl}boronic acid (CAS 2377608-39-2)
- 2,6-Dichloro-9-phenyl-9H-purine (CAS 6971-26-2)
- 2-(3-(P-tolyl)-1H-pyrazol-1-yl)acetic acid (CAS 959573-30-9)
- 1,3,8-Trimethyl-3,9-dihydro-1H-purine-2,6-dione (CAS 88191-01-9)
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