Indapamide EP Impurity B CAS 63968-75-2
| CAS No. | 63968-75-2 |
| Molecular Formula | C16H14ClN3O3S |
| Molecular Weight | 363.82 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Indapamide EP Impurity B (CAS 63968-75-2, C16H14ClN3O3S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Indapamide EP Impurity B (C16H14ClN3O3S) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 11.0, corresponding to approximately 11 ring(s) or double-bond equivalent(s). With a molecular weight of 363.82 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C16H14ClN3O3S |
| Molecular Weight | 363.82 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1975 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Indapamide Standards
- Indapamide Impurity 10 (CAS CATO-C4X-140010)
- Indapamide Impurity 30 (CAS 77083-53-5)
- Indapamide Impurity 31 (CAS 77083-52-4)
- Indapamide (CAS 26807-65-8)
- Indapamide Impurity 7 (CAS 2457316-06-0)
- Indapamide Impurity 24 (CAS CATO-C4X-140024)
- Indapamide Impurity 23 (CAS CATO-C4X-140023)
- Indapamide Impurity 8 (CAS 126750-70-7)
Recommended Standards
- n-(3-Chloroquinoxalin-2-yl)-4-ethoxybenzenesulfonamide (CAS 731795-55-4)
- 7-Chloro-4-((S)-3-methylmorpholin-4-yl)-2-((S)-3-methylmorpholin-4-yl)pyrido[2,3-d]pyrimidine (CAS 1009303-44-9)
- N-(2-Chlorobenzyl)-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidine-6-carboxamide (CAS 946206-77-5)
- Tert-butyl 2-(2-(4-chlorophenyl)-1-((furan-2-ylmethyl)imino)ethyl)hydrazine-1-carboxylate (CAS 1053657-85-4)
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- Baloxavir Impurity 42 (CAS 2365473-17-0)
- Azlocillin Impurity 5 (CAS CATO-C4X-23205)
- Ethyl 1-(but-3-en-1-yl)-2-oxocyclohexanecarboxylate (CAS 61771-76-4)
- Asimadoline (CAS 153205-46-0)
- 6-Oxo-2-(thiophen-2-yl)-1,6-dihydropyrimidine-5-carboxylic acid (CAS 1247406-36-5)
- 6-Bromo-3-methoxy-2-(2-oxo-2-(piperidin-1-yl)ethoxy)benzaldehyde (CAS 1427026-80-9)
- 2-Chloro-3-(1-methanesulfonyl-pyrrolidin-2-yl)-pyrazine (CAS 1316221-58-5)
- Bedaquiline Impurity 26 (CAS 654654-19-0)
- Biotinyl-Neuropeptide W-23 (human) (CAS 1815618-09-7)
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