Indapamide Impurity 30 CAS 77083-53-5
| CAS No. | 77083-53-5 |
| Molecular Formula | C16H16ClN3O3S |
| Molecular Weight | 365.83 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 365.83 g/mol gives Indapamide Impurity 30 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Indapamide Impurity 30 (CAS 77083-53-5, C16H16ClN3O3S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Indapamide Impurity 30 (C16H16ClN3O3S) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H16ClN3O3S |
| Molecular Weight | 365.83 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1979 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Indapamide Standards
- Indapamide Impurity 31 (CAS 77083-52-4)
- Indapamide (CAS 26807-65-8)
- Indapamide EP Impurity B (CAS 63968-75-2)
- Indapamide Impurity 10 (CAS CATO-C4X-140010)
- Indapamide Impurity 24 (CAS CATO-C4X-140024)
- Indapamide Impurity 7 (CAS 2457316-06-0)
- Indapamide Impurity 23 (CAS CATO-C4X-140023)
- Indapamide Impurity 8 (CAS 126750-70-7)
Recommended Standards
- 400075-42-5 5-(4-chlorophenyl)-5-oxo-2-(phenylsulfonyl)pentanamide KS-00002Z3Q (CAS 400075-42-5)
- 2-[(4-chlorophenyl)sulfonyl]-5-oxo-5-phenylpentanamide 303150-90-5 KS-00002Z3K (CAS 303150-90-5)
- Metolazone (CAS 17560-51-9)
- Zidapamide (CAS 75820-08-5)
- Ticagrelor Impurity 109 (CAS CATO-C4X-1093109)
- Rivaroxaban Impurity 62 (CAS 89283-13-6)
- Naltrexone Impurity 26 (CAS CATO-C4X-147526)
- Tert-butyl 3-(4-ethynyl-1H-pyrazol-1-yl)azetidine-1-carboxylate (CAS 2098140-87-3)
- 2-(4-(4-Chlorophenyl)-2-methyl-3-oxo-1,2,4-oxadiazolidin-5-yl)acetic acid (CAS 217466-63-2)
- 4-Methyl-1-(pyridin-4-ylmethyl)-1h-pyrazol-3-amine (CAS 1339751-23-3)
- (S)-Tetrahydrofuran-3-yl (3-nitrobenzyl)carbamate (CAS 914810-53-0)
- (R)-3-Acetyl-5-((S)-sec-butyl)-4-hydroxy-1H-pyrrol-2(5H)-one (CAS 36576-19-9)
- Phenyl(2-(thiophen-2-yl)pyrrolidin-1-yl)methanone (CAS 1355200-79-1)
- Semaglutide Impurity 82 (CAS CATO-C4X-222682)
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