Hydroxyzine Impurity 5 CAS 2469273-48-9
| CAS No. | 2469273-48-9 |
| Molecular Formula | C21H27ClN2O3 |
| Molecular Weight | 390.90 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Hydroxyzine Impurity 5 is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Hydroxyzine Impurity 5 (CAS 2469273-48-9) is a certified pharmaceutical impurity reference standard with the molecular formula C21H27ClN2O3 and a molecular weight of 390.90 g/mol.
Based on its molecular formula C21H27ClN2O3, Hydroxyzine Impurity 5 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 390.90 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Hydroxyzine Impurity 5 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H27ClN2O3 |
| Molecular Weight | 390.90 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2000 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Hydroxyzine Standards
- Hydroxyzine-d8DISCONTINUED (CAS 1189480-47-4)
- Hydroxyzine Impurity 2 (CAS CATO-C4X-16602)
- Hydroxyzine (CAS 68-88-2)
- Hydroxyzine Impurity B Hydrochloride salt (CAS 1263283-80-2)
- Hydroxyzine Impurity 4 (CAS CATO-C4X-16604)
- Hydroxyzine Impurity 1 (CAS 628-89-7)
- Hydroxyzine Pamoate (CAS 10246-75-0)
- Hydroxyzine Impurity 9 (CAS 1031-92-1)
Recommended Standards
- Beclomethasone-Δ17,20 21-Aldehyde(E/Z Mixture) (CAS 1174035-77-8&1174035-80-3)
- Mometasone Furoate EP Impurity Q (CAS 83881-08-7)
- Betamethasone Impurity 124 (CAS 947382-36-7)
- PBB No. 26 (CAS 59080-35-2)
- Fluticasone Impurity 70 (CAS 22593-10-8)
- Bilastine Impurity 126 (CAS CATO-C4X-2253126)
- Dotinurad Impurity 239 (CAS CATO-C4X-2494239)
- 5-Bromo-6-fluoroquinolin-2(1H)-one (CAS 1420792-20-6)
- 5H-Pyrrolo[3,4-b]pyridin-7(6H)-one (CAS 1211584-54-1)
- 1-(2-Hydroxyethyl)-3-(o-tolyl)thiourea (CAS 52266-56-5)
- 3-(2-Benzothienylmethyl)piperidine (CAS 1337034-11-3)
- 6-Bromo-1-chloro-2-ethoxynaphthalene (CAS 1394291-31-6)
- N-(5-bromo-6-methylpyridin-2-yl)isobutyramide (CAS 689749-45-9)
- Semaglutide Impurity 11 (CAS CATO-C4X-222611)
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