Nilotinib Impurity 28 CAS 641569-97-3
| CAS No. | 641569-97-3 |
| Molecular Formula | C19H18N4O2 |
| Molecular Weight | 334.37 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Nilotinib Impurity 28.
CATO supplies Nilotinib Impurity 28 (CAS 641569-97-3), a pharmacopoeial impurity reference standard (molecular formula C19H18N4O2, MW 334.37 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, Nilotinib Impurity 28 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 334.37 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H18N4O2 |
| Molecular Weight | 334.37 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Nitrogen Atoms | 4 |
Related Nilotinib Standards
- Nilotinib Impurity 45 (CAS CATO-C4X-125645)
- Nilotinib Hydrochloride Monohydrate EP Impurity G (CAS 917392-54-2)
- Nilotinib Impurity 20 (CAS CATO-C4X-125620)
- Nilotinib Hydrochloride Monohydrate EP Impurity D (CAS 641569-94-0)
- Nilotinib Impurity 13 (CAS CATO-C4X-125613)
- Nilotinib Impurity 18 (CAS 851137-91-2)
- Nilotinib Impurity 19 (CAS CATO-C4X-125619)
- Nilotinib Impurity 19 (CAS 915711-42-1)
Recommended Standards
- Terbutaline Impurity 37 (CAS 28917-43-3)
- Tetroxoprim (CAS 53808-87-0)
- Ceftriaxone Impurity 31 (CAS CATO-C4X-116331)
- Lenalidomide Impurity 51 (CAS 1063995-41-4)
- Vazegepant Impurity 13 (CAS CATO-C4X-320013)
- Torasemide EP Impurity B (CAS 72811-73-5)
- Semaglutide impurity 249 (CAS CATO-C4X-2226249)
- 4-[(1E)-3-(4-Chlorophenyl)-3-oxoprop-1-en-1-yl]phenyl thiophene-2-carboxylate (CAS 331460-49-2)
- 1-Methyl-5-(tributylstannyl)-1H-pyrazole (CAS 170682-50-5)
- 4-Methanesulfonyl-2-({5-nitro-6-[phenyl(propan-2-yl)amino]pyrimidin-4-yl}amino)butanoic acid (CAS 1025769-91-8)
- Methyl 3-((tert-butoxycarbonyl)amino)-2-oxopropanoate (CAS 436154-66-4)
- Conjugated Linoleic Acid Ethyl Ester, 90% (Mixture of Isomers) (CAS 137142-61-1)
- 2-benzylthiomorpholine (CAS 1354950-27-8)
- Acetyl Hexapeptide-39 (CAS 1382088-38-1)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com