Nilotinib Hydrochloride Monohydrate EP Impurity G CAS 917392-54-2
| CAS No. | 917392-54-2 |
| Molecular Formula | C18H16N4O2 |
| Molecular Weight | 320.35 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Nilotinib Hydrochloride Monohydrate EP Impurity G meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies Nilotinib Hydrochloride Monohydrate EP Impurity G (CAS 917392-54-2), a pharmacopoeial impurity reference standard (molecular formula C18H16N4O2, MW 320.35 g/mol) used for the identification and quantification of trace impurities in APIs.
Based on its molecular formula C18H16N4O2, Nilotinib Hydrochloride Monohydrate EP Impurity G contains a steroid core, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 320.35 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C18H16N4O2 |
| Molecular Weight | 320.35 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Nitrogen Atoms | 4 |
Related Nilotinib Standards
- Nilotinib Impurity 45 (CAS CATO-C4X-125645)
- Nilotinib Impurity 20 (CAS CATO-C4X-125620)
- Nilotinib Impurity 28 (CAS 641569-97-3)
- Nilotinib Hydrochloride Monohydrate EP Impurity D (CAS 641569-94-0)
- Nilotinib Impurity 18 (CAS 851137-91-2)
- Nilotinib Impurity 19 (CAS CATO-C4X-125619)
- Nilotinib Impurity 13 (CAS CATO-C4X-125613)
- Nilotinib Impurity 17 (CAS 916975-92-3)
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