Nilotinib Impurity 18 CAS 851137-91-2

Purity 97%+In StockPharmacopoeial Impurity Standards
CAS No.851137-91-2
Molecular FormulaC17H15N5O
Molecular Weight305.33 g/mol
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Nilotinib Impurity 18 CAS 851137-91-2 chemical structure

Description

CATO supplies Nilotinib Impurity 18 (CAS 851137-91-2), a pharmacopoeial impurity reference standard (molecular formula C17H15N5O, MW 305.33 g/mol) used for the identification and quantification of trace impurities in APIs.

Based on its molecular formula C17H15N5O, Nilotinib Impurity 18 contains a steroid core, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 305.33 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.

This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

Molecular FormulaC17H15N5O
Molecular Weight305.33 g/mol
AppearancePale yellow to yellow crystalline powder
Purity97%+
StorageStore at 2-8°C, protect from light
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityLight-sensitive; avoid direct strong light
Degree of Unsaturation (DBE)13.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1987
Nitrogen Atoms5

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