Etoricoxib Impurity 19 CAS 646459-41-8
| CAS No. | 646459-41-8 |
| Molecular Formula | C21H16ClN3O2S |
| Molecular Weight | 409.89 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Etoricoxib Impurity 19.
CATO supplies Etoricoxib Impurity 19 (CAS 646459-41-8), a pharmacopoeial impurity reference standard (molecular formula C21H16ClN3O2S, MW 409.89 g/mol) used for the identification and quantification of trace impurities in APIs.
Etoricoxib Impurity 19 (C21H16ClN3O2S) contains a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Etoricoxib Impurity 19 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H16ClN3O2S |
| Molecular Weight | 409.89 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Etoricoxib Standards
- Etoricoxib Impurity 32 (CAS 1421227-97-5)
- Etoricoxib Impurity 51 (CAS CATO-C4X-108051)
- Etoricoxib impurity 01 (CAS 646459-49-6)
- Etoricoxib Impurity 89 (CAS CATO-C4X-108089)
- Etoricoxib Impurity 93 (CAS CATO-C4X-108093)
- Etoricoxib Impurity 31 (CAS 2724840-93-9)
- Etoricoxib Impurity 30 (CAS 349536-39-6)
- Etoricoxib Impurity 12 (CAS CATO-C4X-108012)
Recommended Standards
- N-[(1E)-{[(4-chlorophenyl)methoxy]imino}methyl]-5-cyano-3-methyl-4-phenylthiophene-2-carboxamide (CAS 338968-35-7)
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- N-(benzo[d][1,3]dioxol-5-ylmethyl)-1-(1-((2-chlorothiazol-5-yl)methyl)-1H-indol-3-yl)methanimine (CAS 866131-58-0)
- Rivaroxaban Impurity 130 (CAS 1325210-62-5)
- Etrasimod Impurity 29 (CAS CATO-C4X-321429)
- Biotin EP Impurity C (CAS 22342-46-7)
- Amoxapine Impurity 2 (CAS CATO-C4X-25822)
- Olanzapine (CAS 132539-06-1)
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- Fluphenazine-d8 (CAS 1323633-98-2)
- (E)-but-2-ene-1,4-diylbis(triphenylphosphonium) chloride (CAS 106423-29-4)
- 2-[(4-bromophenyl)methoxy]-3-methoxybenzaldehyde (CAS 588679-50-9)
- 4-(4-Bromomethylphenyl)-thiazole (CAS 1859084-24-4)
- Endo-[Glu]31-Liraglutide (CAS CATO-C4X-199234)
Why CATO?
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- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com