Doxorubicin Impurity 1 CAS 64845-67-6
| CAS No. | 64845-67-6 |
| Molecular Formula | C19H12O6 |
| Molecular Weight | 336.29 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Doxorubicin Impurity 1 (CAS 64845-67-6, C19H12O6) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C19H12O6, Doxorubicin Impurity 1 contains a flavonoid core, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 336.29 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), Doxorubicin Impurity 1 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C19H12O6 |
| Molecular Weight | 336.29 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1975 |
Related Doxorubicin Standards
- Doxorubicin Impurity 35 (CAS CATO-C4X-203335)
- Doxorubicin Impurity 15 (CAS 59325-97-2)
- Doxorubicin Impurity 12 (CAS CATO-C4X-203312)
- Doxorubicin Impurity 6 (CAS CATO-C4X-20336)
- Doxorubicin Impurity 6 (CAS 32384-98-8)
- Doxorubicin Impurity 7 (CAS 105612-58-6)
- Doxorubicin Impurity 8 (CAS 20982-41-6)
- Doxorubicin Impurity 14 (CAS CATO-C4X-203314)
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