Haloperidol Decanoate EP Impurity K CAS 65135-24-2
| CAS No. | 65135-24-2 |
| Molecular Formula | C33H45ClFNO3 |
| Molecular Weight | 558.17 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Haloperidol Decanoate EP Impurity K (CAS 65135-24-2, C33H45ClFNO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C33H45ClFNO3, Haloperidol Decanoate EP Impurity K contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 558.17 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C33H45ClFNO3 |
| Molecular Weight | 558.17 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1975 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Haloperidol Standards
- Haloperidol Impurity 10 (CAS 100442-88-4)
- Haloperidol EP Impurity D (CAS 67987-08-0)
- Haloperidol Decanoate N-Oxide (CAS 2749298-36-8)
- Haloperidol Decanoate EP Impurity J (CAS 1797983-18-6)
- Haloperidol Impurity 13 (CAS CATO-C4X-146113)
- Haloperidol Impurity 14 (CAS CATO-C4X-146114)
- Haloperidol Decanoate EP Impurity B (CAS CATO-C4X-146130)
- Haloperidol Decanoate (CAS 74050-97-8)
Recommended Standards
- 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-8-iodotetradecane (CAS 109574-84-7)
- 4,4′′′-Diiodo-1,1′:4′,1′′:4′′,1′′′-quaterphenyl (CAS 1770-82-7)
- Bromopyrogallol Red (CAS 16574-43-9)
- 231301-26-1 1-Benzoyl-3(5)-(tridecafluoro-1-hexyl)-5(3)-(trifluoromethyl)pyrazole MFCD01075249 (CAS 231301-26-1)
- Valsartan Impurity 58 (CAS CATO-C4X-105758)
- Lifitegrast impurity 94 (CAS CATO-C4X-240994)
- Tadalafil Impurity 31 (CAS 2058231-08-4)
- [(S)-1-((S)-2-Amino-3-methyl-butyryl)-pyrrolidin-2-ylmethyl]-cyclopropyl-carbamic acid benzyl ester (CAS 1354025-64-1)
- Bezafibrate Isopropyl Ester (CAS 153758-85-1)
- Methyl 4-(difluoromethoxy)-1-naphthoate (CAS 1261559-96-9)
- Methyl 4,4,4-trifluoro-3-(trifluoromethyl)butyrate (CAS 674335-88-7)
- 2,2'-(Prop-2-yn-1-ylazanediyl)diacetic acid (CAS 1021182-50-2)
- 3-Chloro-7-morpholinoquinoline-8-carbonitrile (CAS 88347-06-2)
- Semaglutide impurity 250 (CAS CATO-C4X-2226250)
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