Haloperidol EP Impurity D CAS 67987-08-0
| CAS No. | 67987-08-0 |
| Molecular Formula | C32H36Cl2N2O3 |
| Molecular Weight | 567.55 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Haloperidol EP Impurity D (CAS 67987-08-0) is a certified pharmaceutical impurity reference standard with the molecular formula C32H36Cl2N2O3 and a molecular weight of 567.55 g/mol.
Based on its molecular formula C32H36Cl2N2O3, Haloperidol EP Impurity D contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 567.55 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Haloperidol EP Impurity D meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C32H36Cl2N2O3 |
| Molecular Weight | 567.55 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1976 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Haloperidol Standards
- Haloperidol Decanoate EP Impurity K (CAS 65135-24-2)
- Haloperidol Impurity 10 (CAS 100442-88-4)
- Haloperidol Impurity 13 (CAS CATO-C4X-146113)
- Haloperidol Impurity 14 (CAS CATO-C4X-146114)
- Haloperidol Decanoate N-Oxide (CAS 2749298-36-8)
- Haloperidol Decanoate EP Impurity J (CAS 1797983-18-6)
- Haloperidol Impurity 12 (CAS CATO-C4X-146112)
- Haloperidol Decanoate EP Impurity B (CAS CATO-C4X-146130)
Recommended Standards
- Gefitinib Impurity 84 (CAS CATO-C4X-111784)
- Methyl 5-Acetamido-7,8,9-tri-O-acetyl-5-N,4-O-carbonyl-3,5-dideoxy-2-S-phenyl-2-thio-D-glycero-β-D-galacto-2-nonulopyranosylonate (CAS 934591-76-1)
- N-Nitroso Gentamicin impurity 30 (CAS CATO-C4X-148030)
- Ubrogepant Impurity 8 (CAS CATO-C4X-34028)
- Metaraminol Impurity 79 (CAS CATO-C4X-225279)
- Terbutaline Impurity 9 (CAS 81732-54-9)
- Rupatadine Impurity 34 (CAS 2724877-90-9)
- (S)-5-(2-Chloroacetyl)-3,4-dihydroxyfuran-2(5H)-one (CAS 120912-36-9)
- Rel-(4AS,7aR)-4-methylhexahydropyrrolo[3,4-b][1,4]oxazin-3(2H)-one (CAS 1487347-49-8)
- 2-((4-Fluorophenyl)thio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide (CAS 895489-63-1)
- 4-Iodo-1H-pyrrole-2-carbonitrile (CAS 87721-22-0)
- 2-Bromo-N-(3-methoxybenzyl)acetamide (CAS 936356-12-6)
- Acetylsulfenyl Chloride (CAS 6405-82-9)
- Semaglutide impurity 211 (CAS CATO-C4X-2226211)
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