(3R,5S)-Atorvastatin EP Impurity B (single configuration) Calcium salt CAS 651770-09-1
| CAS No. | 651770-09-1 |
| Molecular Formula | 2*C33H34FN2O5 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of (3R,5S)-Atorvastatin EP Impurity B (single configuration) Calcium salt is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies (3R,5S)-Atorvastatin EP Impurity B (single configuration) Calcium salt (CAS 651770-09-1), a pharmacopoeial impurity reference standard (molecular formula C33H34FN2O5Ca, MW 597.72 g/mol) used for the identification and quantification of trace impurities in APIs.
Based on its molecular formula C33H34FN2O5Ca, (3R,5S)-Atorvastatin EP Impurity B (single configuration) Calcium salt contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 597.72 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), (3R,5S)-Atorvastatin EP Impurity B (single configuration) Calcium salt meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | 2*C33H34FN2O5 Ca |
| Molecular Weight | 597.72 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 17.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Recommended Standards
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- 6,6,8,8-Tetramethyl-7-oxa-1,3-diazaspiro[4.4]Nonane-2,4-dione (CAS 1394631-64-1)
- 2-(4-Propylphenyl)propan-2-ol (CAS 1267664-91-4)
- Mirabegron Impurity 43 (CAS 1627515-83-6)
- 3-Amino-4-mercaptophenol (CAS 228564-80-5)
- Ac, Gastrin Releasing Peptide (20-27), porcine (CAS 77714-20-6)
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