Doxofylline Impurity 12 CAS 652-37-9
| CAS No. | 652-37-9 |
| Molecular Formula | C9H10N4O4 |
| Molecular Weight | 238.20 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies Doxofylline Impurity 12 (CAS 652-37-9), a pharmacopoeial impurity reference standard (molecular formula C9H10N4O4, MW 238.20 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage, Doxofylline Impurity 12 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 238.20 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C9H10N4O4 |
| Molecular Weight | 238.20 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 4 |
Related Doxofylline Standards
- Doxofylline Impurity 20 (CAS 1021-65-4)
- Doxofylline Impurity 40 (CAS 23146-07-8)
- Doxofylline Impurity 28 (CAS 62637-09-6)
- Doxofylline Impurity 31 (CAS CATO-C4X-151331)
- Doxofylline Impurity 1 (CAS 1429636-74-7)
- Doxofylline impurity 46 (CAS CATO-C4X-151346)
- Doxofylline Impurity 10 (CAS CATO-C4X-151310)
- Doxofylline Impurity 33 (CAS CATO-C4X-151333)
Recommended Standards
- 333433-95-7 2-[Methyl(4-nitro-2,1,3-benzoxadiazol-5-yl)amino]ethanol MFCD00582730 (CAS 333433-95-7)
- Propionaldehyde-2,4-Dinitrophenylhydrazone (CAS 725-00-8)
- Propionaldehyde 2,4-Dinitrophenylhydrazone (CAS 72490-63-2)
- Acetone-2,4-Dinitrophenylhydrazone (CAS 1567-89-1)
- Repaglinide EP Impurity D (CAS 147770-06-7)
- Ipratropium Impurity 14 (CAS CATO-C4X-166514)
- Peridine Impurity 20 (CAS 852627-75-9)
- 2-Chlorophenethyl quinoline-4-carboxylate (CAS 6633-64-3)
- Candesartan Cilexetil Impurity 31 (CAS CATO-C4X-123431)
- 6,8-Dichloro-2,2-difluoro-[1,3]dioxolo[4,5-g]quinazoline (CAS 2306276-15-1)
- (S)-2-(2-(2-(2-Amino-3-(1H-imidazol-4-yl)propanamido)acetamido)acetamido)acetic acid (CAS 33001-21-7)
- 2-(Bromomethyl)-4-fluoropyridine (CAS 1227606-51-0)
- N-(3,5-dichloro-2,6-dimethoxybenzoyl)-N'-(2,3,4,5,6-pentafluorophenyl)urea (CAS 680579-31-1)
- Semaglutide impurity 57 (CAS 2773558-06-6)
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