Doxofylline Impurity 40 CAS 23146-07-8
| CAS No. | 23146-07-8 |
| Molecular Formula | C10H12N4O3 |
| Molecular Weight | 236.23 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Doxofylline Impurity 40 (CAS 23146-07-8, C10H12N4O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Doxofylline Impurity 40 (C10H12N4O3) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C10H12N4O3 |
| Molecular Weight | 236.23 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1963 |
| Nitrogen Atoms | 4 |
Related Doxofylline Standards
- Doxofylline Impurity 20 (CAS 1021-65-4)
- Doxofylline Impurity 12 (CAS 652-37-9)
- Doxofylline Impurity 28 (CAS 62637-09-6)
- Doxofylline Impurity 31 (CAS CATO-C4X-151331)
- Doxofylline Impurity 1 (CAS 1429636-74-7)
- Doxofylline impurity 46 (CAS CATO-C4X-151346)
- Doxofylline Impurity 10 (CAS CATO-C4X-151310)
- Doxofylline Impurity 33 (CAS CATO-C4X-151333)
Recommended Standards
- Zolmitriptan Impurity 43 (CAS CATO-C4X-135143)
- Nicardipine Impurity 46 (CAS CATO-C4X-171046)
- Zolmitriptan Impurity 29 (CAS CATO-C4X-135129)
- Theophylline Impurity 15 (CAS CATO-C4X-182315)
- Pioglitazone impurity 42 (CAS CATO-C4X-138342)
- Mitoxantrone EP Impurity A (CAS 89991-52-6)
- Gliquidone Impurity 8 (CAS CATO-C4X-30008)
- 4-Bromo-N1,N1-dimethylbenzene-1,3-diamine (CAS 90555-68-3)
- 2-(4-Bromophenyl)isoindolin-1-one (CAS 4778-87-4)
- 6,6-Dimethylbicyclo[3.1.1]hept-2-ene-2-ethanamine (CAS 13296-30-5)
- 4-Methoxystyrene (stabilized with TBC) (CAS 637-69-4)
- N-(tert-Butyl)-6,8-dichloro-2-oxo-2H-chromene-3-carboxamide (CAS 701940-72-9)
- (S)-(2-Methyloxiran-2-yl)methyl 4-nitrobenzenesulfonate (CAS 683276-63-3)
- Semaglutide impurity 96 (CAS CATO-C4X-222696)
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