N-Formyl 2-chloro-5-trifluoromethylaniline CAS 657-63-6
| CAS No. | 657-63-6 |
| Molecular Formula | C8H5ClF3NO |
| Molecular Weight | 223.58 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
N-Formyl 2-chloro-5-trifluoromethylaniline (CAS 657-63-6), molecular formula C8H5ClF3NO and molecular weight 223.58 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, N-Formyl 2-chloro-5-trifluoromethylaniline is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 223.58 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures N-Formyl 2-chloro-5-trifluoromethylaniline under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C8H5ClF3NO |
| Molecular Weight | 223.58 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
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Recommended Standards
- n-(4-Chlorophenyl)-2,2,2-trifluoroacetamide (CAS 404-25-1)
- N-Hydroxy-2-(trifluoromethoxy)benzene carboximidoyl chloride (CAS 74467-04-2)
- N-(3-Chlorophenyl)-2,2,2-trifluoroacetamide (CAS 40410-54-6)
- Sorafenib Impurity 57 (CAS 656-96-2)
- 2-(1-(3-Chlorophenyl)-1H-pyrazol-5-yl)thiazole (CAS 1269293-24-4)
- 5,8-Dichloro-4-hydroxyquinoline-3-carboxylic acid (CAS 35973-26-3)
- 6-Bromothieno[3,2-d]pyrimidine-2,4(1H,3H)-dione (CAS 1388027-23-3)
- (S)-N,2-Dihydroxypropanimidamide (CAS 1609388-55-7)
- (2-(1H-Imidazol-1-yl)pyrimidin-4-yl)boronic acid (CAS 1259224-56-0)
- Lasmiditan Impurity 67 (CAS CATO-C4X-247867)
- Baclofen Impurity 10 (CAS 1346603-21-1)
- 3-(4-(3-((tert-Butyldiphenylsilyl)oxy)propyl)phenyl)-4-nitropyridine (CAS 2267291-19-8)
- 2-Bromo-5-methoxypyridin-3-ol (CAS 1256833-74-5)
- Tirzepatide Impurity 44 (CAS CATO-C4X-324044)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com