Fluocinolone Acetonide EP Impurity B CAS 65751-34-0
| CAS No. | 65751-34-0 |
| Molecular Formula | C23H28F2O6 |
| Molecular Weight | 438.46 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Fluocinolone Acetonide EP Impurity B is closely related to a flavonoid core, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Fluocinolone Acetonide EP Impurity B (CAS 65751-34-0) is a certified pharmaceutical impurity reference standard with the molecular formula C23H28F2O6 and a molecular weight of 438.46 g/mol.
The molecular framework of Fluocinolone Acetonide EP Impurity B (C23H28F2O6) is characterized by a flavonoid core, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Fluocinolone Acetonide EP Impurity B under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C23H28F2O6 |
| Molecular Weight | 438.46 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1975 |
| Halogen Content | F-containing |
Related Fluocinolone Standards
- Fluocinolone Acetonide Impurity 46 (CAS CATO-C4X-238146)
- Fluocinolone Acetonide EP Impurity E (CAS 68352-03-4)
- Fluocinolone Acetonide Impurity 42 (CAS 3793-12-2)
- Fluocinolone Acetonide Impurity 16 (CAS CATO-C4X-238116)
- Fluocinolone Acetonide EP Impurity D (CAS 13242-30-3)
- Fluocinolone Acetonide EP Impurity I (CAS CATO-C4X-23819)
- Fluocinolone Acetonide Impurity 38 (CAS CATO-C4X-238138)
- Fluocinolone Acetonide Impurity 41 (CAS CATO-C4X-238141)
Recommended Standards
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- Erlotinib Impurity 80 (CAS 2518426-66-7)
- Glucosamine Hydrochloride Impurity F (CAS 3646-68-2)
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Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com