Fluocinolone Acetonide EP Impurity E CAS 68352-03-4
| CAS No. | 68352-03-4 |
| Molecular Formula | C24H29FO6 |
| Molecular Weight | 432.48 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 432.48 g/mol gives Fluocinolone Acetonide EP Impurity E distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Fluocinolone Acetonide EP Impurity E (CAS 68352-03-4) is a certified pharmaceutical impurity reference standard with the molecular formula C24H29FO6 and a molecular weight of 432.48 g/mol.
Structurally, Fluocinolone Acetonide EP Impurity E (C24H29FO6) contains a flavonoid core, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 10.0, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 432.48 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Fluocinolone Acetonide EP Impurity E meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C24H29FO6 |
| Molecular Weight | 432.48 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1976 |
| Halogen Content | F-containing |
Related Fluocinolone Standards
- Fluocinolone Acetonide Impurity 46 (CAS CATO-C4X-238146)
- Fluocinolone Acetonide EP Impurity B (CAS 65751-34-0)
- Fluocinolone Acetonide EP Impurity F (CAS 1526-01-8)
- Fluocinolone Acetonide Impurity 43 (CAS 3802-45-7)
- Fluocinolone Acetonide Impurity 42 (CAS 3793-12-2)
- Fluocinolone Acetonide Impurity 16 (CAS CATO-C4X-238116)
- Fluocinolone Acetonide EP Impurity D (CAS 13242-30-3)
- Fluocinolone Acetonide EP Impurity I (CAS CATO-C4X-23819)
Recommended Standards
- Osimertinib Impurity 83 (CAS CATO-C4X-204583)
- Momelotinib impurity 2 (CAS CATO-C4X-33772)
- Fluticasone Impurity 54 (CAS 4571-51-1)
- Methyl 2-(2-(N-(2-(1H-indol-3-yl)ethyl)sulfamoyl)-4,5-dimethoxyphenyl)acetate (CAS 1022528-89-7)
- Minoxidil Impurity 49 (CAS CATO-C4X-170049)
- Mirogabalin Impurity 207 (CAS CATO-C4X-2924207)
- Telmisartan EP Impurity A (CAS 152628-02-9)
- 2-Acetyl-5-chloropyridine (CAS 94952-46-2)
- 4-Methyl-N-((4-methyl-5-((4-(trifluoromethyl)benzyl)thio)-4H-1,2,4-triazol-3-yl)methyl)benzenesulfonamide (CAS 338953-94-9)
- 2α-Cyano-Ethisterone (CAS 13648-12-9)
- 1-({[(3-Methylbenzoyl)oxy]imino}methyl)-3-nitrobenzene (CAS 303987-16-8)
- Boronic acid, b-[3-[[[(2-fluorophenyl)methyl]amino]carbonyl]phenyl]- (CAS 874288-21-8)
- tert-Butyl (4-hydroxy-2,6-dimethylphenyl)carbamate (CAS 1313430-55-5)
- (β-Asp5)-Delta-Sleep Inducing Peptide (CAS 82602-88-8)
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