Lamivudine EP Impurity F CAS 66-22-8
| CAS No. | 66-22-8 |
| Molecular Formula | C4H4N2O2 |
| Molecular Weight | 112.09 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Lamivudine EP Impurity F is closely related to an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Lamivudine EP Impurity F (CAS 66-22-8, C4H4N2O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Lamivudine EP Impurity F (C4H4N2O2) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C4H4N2O2 |
| Molecular Weight | 112.09 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 2 |
Related Lamivudine Standards
- Lamivudine EP Impurity E (CAS 71-30-7)
- Lamivudine EP Impurity F-13C-15N2 (CAS 181517-11-3)
- Lamivudine Impurity 5 (CAS 2032-34-0)
- Lamivudine Impurity 17 (CAS 72702-38-6)
- Lamivudine EP Impurity I (CAS 145918-75-8)
- Lamivudine 5-monophosphate ammonium salt (CAS 1187058-40-7)
- Lamivudine 5-diphosphate ammonium salt (CAS 1187058-41-8)
- Lamivudine 5-triphosphate triethylammonium salt (CAS 1187058-42-9)
Recommended Standards
- 1H-1,2,4-triazole-1-carboxamide (CAS 35101-89-4)
- Ornidazole Impurity 5 (CAS 16042-25-4)
- 2423-84-9 Pyrazine 1,4-Dioxide Pyrazine Di-N-oxide Pyrazine Dioxide Pyrazine N,N'-Dioxide (CAS 2423-84-9)
- Azacitidine Impurity 51 (CAS 931-86-2)
- Saxagliptin Impurity 21 (CAS 871727-40-1)
- Canagliflozin Impurity 63 (CAS CATO-C4X-112363)
- Cefotaxime Impurity 78 (CAS CATO-C4X-120178)
- 3-(4-Iodophenyl)oxetane-3-carboxylic acid (CAS 1416323-19-7)
- Ethyl 5-cyano-6-methyl-2-(piperazin-1-yl)nicotinate (CAS 402479-97-4)
- 2,2'-(Butane-1,4-diylbis(sulfanediyl))diacetic acid (CAS 13821-57-3)
- Cefepime EP Impurity A (CAS 97164-57-3)
- N-Fmoc DMNB-L-serine (CAS 628280-43-3)
- 5-[(4-amino-2-chlorophenoxy)methyl]-2-furoic acid (CAS 1245808-08-5)
- 69558-55-0 O3Y80ZF13F Thymopentin Thymopentin [USAN:INN:BAN] L-Tyrosine, N-(N-(N-(N2-L-arginyl-L-lysyl)-L-alpha-aspartyl)-L-valyl)- L-Tyrosine, N-(N-(N-(N(sup 2)-L-arginyl-L-lysyl)-L-alpha-aspartyl)-L-valyl)- Thymopentine [French] Thymopentinum [Latin] Timopentina [Spanish] Thymopoietin 32-36 TP-5 Thymopoietin pentapeptide ORF-15244 Thymopentine Thymopentinum Timopentina ORF 15244 UNII-O3Y80ZF13F (CAS 69558-55-0)
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