Propafenone EP Impurity H CAS 487-26-3
| CAS No. | 487-26-3 |
| Molecular Formula | C15H12O2 |
| Molecular Weight | 224.25 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C15H12O2, Propafenone EP Impurity H contains a carboxylic acid group, a hydroxyl group, an ether linkage, a polycyclic aromatic system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 224.25 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Propafenone EP Impurity H (CAS 487-26-3) is a certified pharmaceutical impurity reference standard with the molecular formula C15H12O2 and a molecular weight of 224.25 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H12O2 |
| Molecular Weight | 224.25 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
Related Propafenone Standards
- Propafenone Impurity 30 (CAS 17002-31-2)
- Propafenone EP Impurity H(R-isomer) (CAS 27439-12-9)
- Propafenone EP Impurity A (CAS 3516-95-8)
- Propafenone Impurity 28 (CAS CATO-C4X-132228)
- Propafenone Impurity 29 (CAS 36941-00-1)
- Propafenone Impurity 31 (CAS CATO-C4X-132231)
- Propafenone RC 6 (CAS 189766-45-8)
- Propafenone Impurity 23 (CAS CATO-C4X-132223)
Recommended Standards
- Ketoprofen EP Impurity A (CAS 66067-44-5)
- Bisoprolol Impurity 83 (CAS CATO-C4X-124783)
- Loxoprofen impurity 120 (CAS CATO-C4X-1488120)
- Bisoprolol Impurity 101 (CAS CATO-C4X-1247101)
- Remdesivir Impurity 27 (CAS CATO-C4X-210027)
- Sunitinib Impurity 89 (CAS CATO-C4X-133389)
- Lisinopril EP Impurity A (CAS 1012-05-1)
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