Nintedanib Impurity 184 CAS 873376-89-7
| CAS No. | 873376-89-7 |
| Molecular Formula | C8H9ClN2O |
| Molecular Weight | 184.62 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Nintedanib Impurity 184 (CAS 873376-89-7, C8H9ClN2O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Nintedanib Impurity 184 (C8H9ClN2O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Nintedanib Impurity 184 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H9ClN2O |
| Molecular Weight | 184.62 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Nintedanib Standards
- Nintedanib Impurity 67 (CAS 40872-87-5)
- Nintedanib Impurity 39 (CAS 3395-81-1)
- Nintedanib Impurity 44 (CAS 3395-80-0)
- Nintedanib Impurity 45 (CAS 70380-66-4)
- Nintedanib Impurity 38 (CAS 58378-33-9)
- Nintedanib Impurity 42 (CAS 2186-92-7)
- Nintedanib Impurity 43 (CAS 59276-28-7)
- Nintedanib Impurity 66 (CAS 707-07-3)
Recommended Standards
- Ketoprofen Impurity 43 (CAS 34040-63-6)
- Dyclonine Impurity 20 (CAS 35999-21-4)
- Azelastine Impurity 21 (CAS 57676-51-4)
- Dyclonine Impurity 21 (CAS 7182-38-9)
- Letermovir Impurity 4 (CAS 1791412-07-1)
- Verapamil Impurity N2 (CAS 3017-96-7)
- Itraconazole Impurity 37 (CAS 154003-23-3)
- 2-(1H-Indol-3-yl)naphthalene-1,4-dione (CAS 53475-83-5)
- 1-Benzyl-1H-benzoimidazol-5-ylaminedihydrochloride (CAS 1185300-90-6)
- Baricitinib Impurity 127 (CAS CATO-C4X-2260127)
- (R)-N,N-dimethylpyrrolidine-3-carboxamide hydrochloride (CAS 1315592-39-2)
- (e)-2-(2-Nitroprop-1-en-1-yl)dibenzo[b,d]furan (CAS 893763-95-6)
- FA-Gly-Phe-NH? (CAS 26400-34-0)
- Semaglutide Impurity 15 (CAS CATO-C4X-222615)
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