Tramadol Hydrochloride EP Impurity B CAS 66170-32-9
| CAS No. | 66170-32-9 |
| Molecular Formula | C16H23NO |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 281.82 g/mol gives Tramadol Hydrochloride EP Impurity B distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Tramadol Hydrochloride EP Impurity B (CAS 66170-32-9), a pharmacopoeial impurity reference standard (molecular formula C16H23NOHCl, MW 281.82 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Tramadol Hydrochloride EP Impurity B (C16H23NOHCl) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 281.82 g/mol, it falls into the medium-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Tramadol Hydrochloride EP Impurity B under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C16H23NO HCl |
| Molecular Weight | 281.82 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1975 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Tramadol Standards
- (+)-Tramadol-D6 Hydrochloride (CAS 1109217-84-6)
- Tramadol-d6 HCl (N,N-dimethyl-d6) (mixture of diastereomers) (CAS 1189374-50-2)
- (-)-Tramadol (CAS 123134-25-8)
- Tramadol N-Oxide (CAS 147441-56-3)
- (-)-Tramadol Hydrochloride (CAS 148229-79-2)
- Tramadol EP Impurity A (CAS 152538-36-8)
- Tramadol Impurity 2 (CAS 187219-95-0)
- Tramadol Impurity 1 (CAS 1884-42-0)
Recommended Standards
- Topiroxostat Impurity 59 (CAS 19717-43-2)
- Otilonium Bromide Impurity 1 (CAS 255062-85-2)
- Vibegron Impurity 16 (CAS CATO-C4X-237616)
- Eugenol EP Impurity M (CAS 4433-08-3)
- 2-(Cyclopropylamino)-3-(4,5-dimethyl-1h-imidazol-1-yl)propanamide (CAS 1249154-77-5)
- Ethyl 2-bromo-2-(4-nitrophenyl)acetate (CAS 4691-72-9)
- N'-(4-Nitro-phenyl)-hydrazinecarboxylic acid tert-butyl ester (CAS 92491-67-3)
- H-Ala-Pro-pNA (CAS 60189-44-8)
- Formaldehyde, polymer with 2-methylphenol and phenol (CAS 26354-11-0)
- Acetyl-(Leu28·31)-Neuropeptide Y (24-36) (CAS 155709-24-3)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com