Fluocortolone Impurity 12 CAS 66233-46-3
| CAS No. | 66233-46-3 |
| Molecular Formula | C27H36F2O5 |
| Molecular Weight | 478.57 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Fluocortolone Impurity 12 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Fluocortolone Impurity 12 (CAS 66233-46-3) is a certified pharmaceutical impurity reference standard with the molecular formula C27H36F2O5 and a molecular weight of 478.57 g/mol.
The molecular framework of Fluocortolone Impurity 12 (C27H36F2O5) is characterized by a steroid core, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C27H36F2O5 |
| Molecular Weight | 478.57 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1975 |
| Halogen Content | F-containing |
Related Fluocortolone Standards
- Fluocortolone Impurity 10 (CAS CATO-C4X-223010)
- Fluocortolone Impurity 11 (CAS CATO-C4X-223011)
- Fluocortolone Hexanoate (CAS 303-40-2)
- Fluocortolone Pivalate EP Impurity D (CAS CATO-C4X-223014)
- Fluocortolone Impurity 5 (CAS CATO-C4X-22305)
- Fluocortolone Impurity 7 (CAS CATO-C4X-22307)
- Fluocortolone Impurity 15 (CAS 34097-16-0)
- Fluocortolone Impurity 6 (CAS 36130-02-6)
Recommended Standards
- Diflucortolone 21-Valerate (CAS 59198-70-8)
- 2-Cyano-3-[5-[4-(diphenylamino)phenyl]thieno[3,2-b]thien-2-yl]-2-propenoic acid (CAS 1092363-69-3)
- Flupentixol Impurity 30 (CAS CATO-C4X-189530)
- Di-tert-butyl 2,2'-((pyrimidine-2,4-diylbis(oxy))bis(methylene))bis(pyrrolidine-1-carboxylate) (CAS 1261236-18-3)
- Resmetirom Impurity 44 (CAS CATO-C4X-291244)
- Gadoteridol Impurity 49 (CAS CATO-C4X-225749)
- Fluticasone Impurity 110 (CAS CATO-C4X-1650110)
- 3-(4-Methoxyphenyl)-3-trifluoromethylpropiophenone (CAS 898776-04-0)
- Sodium palmitoyl-L-prolinate (CAS 58725-33-0)
- 3-Ethoxy-N-[2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-pyridyl]propanamide (CAS 2246862-89-3)
- Ethyl 2-benzamido-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylate (CAS 63274-52-2)
- (R)-1-Amino-3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)propan-2-ol (CAS 925232-40-2)
- N4-benzyl-5-nitropyrimidine-4,6-diamine (CAS 23120-18-5)
- Semaglutide impound 212 (CAS CATO-C4X-2226212)
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