Fluocortolone Pivalate EP Impurity D CAS CATO-C4X-223014
| CAS No. | CATO-C4X-223014 |
| Molecular Formula | C27H39FO5 |
| Molecular Weight | 462.59 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Fluocortolone Pivalate EP Impurity D is closely related to a steroid core, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Fluocortolone Pivalate EP Impurity D (CAS CATO-C4X-223014, C27H39FO5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Fluocortolone Pivalate EP Impurity D (C27H39FO5) contains a steroid core, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 8.0, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 462.59 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C27H39FO5 |
| Molecular Weight | 462.59 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | ≥95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
Related Fluocortolone Standards
- Fluocortolone Impurity 6 (CAS 36130-02-6)
- Fluocortolone Impurity 9 (CAS CATO-C4X-22309)
- Fluocortolone Pivalate (CAS 29205-06-9)
- Fluocortolone Impurity 8 (CAS CATO-C4X-22308)
- Fluocortolone Hexanoate (CAS 303-40-2)
- Fluocortolone Impurity 10 (CAS CATO-C4X-223010)
- Fluocortolone Impurity 11 (CAS CATO-C4X-223011)
- Fluocortolone Impurity 12 (CAS 66233-46-3)
Recommended Standards
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- Levonorgestrel EP Impurity B (CAS 19914-67-1)
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- Lovastatin Impurity 8 (CAS 86827-77-2)
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- (R)-tert-Butyl 2-(4-(4-chlorophenyl)thiazol-2-yl)piperidine-1-carboxylate (CAS 1089729-73-6)
- Gadolinium(III) sulfate (CAS 155788-75-3)
- (Des-Thr?)-Glucagon trifluoroacetate salt (CAS 1802078-27-8)
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