Sulfasalazine EP Impurity F CAS 66364-71-4
| CAS No. | 66364-71-4 |
| Molecular Formula | C18H14N4O5S |
| Molecular Weight | 398.39 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Sulfasalazine EP Impurity F meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Sulfasalazine EP Impurity F (CAS 66364-71-4) is a certified pharmaceutical impurity reference standard with the molecular formula C18H14N4O5S and a molecular weight of 398.39 g/mol.
The molecular framework of Sulfasalazine EP Impurity F (C18H14N4O5S) is characterized by a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C18H14N4O5S |
| Molecular Weight | 398.39 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1975 |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 1 |
Related Sulfasalazine Standards
- Sulfasalazine (CAS 599-79-1)
- Sulfasalazine-D4 (CAS 1346606-50-5)
- Sulfasalazine impurity 14 (CAS 42753-55-9)
- Sulfasalazine Impurity 17 (CAS CATO-C4X-141917)
- Sulfasalazine EP Impurity D (CAS 66364-70-3)
- Sulfasalazine Impurity 27 (CAS 501111-03-1)
- Sulfasalazine Impurity 20 (CAS CATO-C4X-141920)
- Sulfasalazine EP Impurity C (CAS 66030-25-9)
Recommended Standards
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- Avatrombopag Impurity 109 (CAS CATO-C4X-2234109)
- Urapidil Impurity 54 (CAS 13300-33-9)
- Emedastine EP Impurity C (CAS 122423-32-9)
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- Furan-2-yl(4-isopropylphenyl)methanol (CAS 944698-40-2)
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- 1-((Benzyloxy)methyl)-4-bromo-1H-imidazole-5-carbaldehyde (CAS 189014-06-0)
- Benzyl N-{[4-(cyclohexylcarbamoyl)phenyl]methyl}carbamate (CAS 477847-74-8)
- Acetyl Tetrapeptide- 15 (CAS 928007-64-1)
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