Sulfasalazine Impurity 20 CAS CATO-C4X-141920
| CAS No. | CATO-C4X-141920 |
| Molecular Formula | C18H13N3O4 |
| Molecular Weight | 335.31 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Sulfasalazine Impurity 20 (CAS CATO-C4X-141920, C18H13N3O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Sulfasalazine Impurity 20 (C18H13N3O4) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H13N3O4 |
| Molecular Weight | 335.31 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 3 |
Related Sulfasalazine Standards
- Sulfasalazine EP Impurity C (CAS 66030-25-9)
- Sulfasalazine Impurity 27 (CAS 501111-03-1)
- Sulfasalazine EP Impurity I (CAS 21542-82-5)
- Sulfasalazine EP Impurity I (CAS 1310803-27-0)
- Sulfasalazine Impurity 2 (RRT 0.75) (CAS 139-56-0)
- Sulfasalazine Impurity 14 (CAS 330833-91-5)
- Sulfasalazine EP Impurity D (CAS 66364-70-3)
- Sulfasalazine Impurity 24 (CAS 409357-24-0)
Recommended Standards
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