Linagliptin Impurity 9 CAS 668270-11-9
| CAS No. | 668270-11-9 |
| Molecular Formula | C25H28N8O2 |
| Molecular Weight | 472.54 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 472.54 g/mol gives Linagliptin Impurity 9 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Linagliptin Impurity 9 (CAS 668270-11-9, C25H28N8O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Linagliptin Impurity 9 (C25H28N8O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C25H28N8O2 |
| Molecular Weight | 472.54 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Nitrogen Atoms | 8 |
Related Linagliptin Standards
- Linagliptin (CAS 668270-12-0)
- Linagliptin Impurity 122 (CAS 2446799-72-8)
- Linagliptin impurity 137 (CAS CATO-C4X-1101137)
- Linagliptin impurity 141 (CAS CATO-C4X-1101141)
- Linagliptin impurity 154 (CAS 1383917-84-7)
- Linagliptin Form A (CAS CATO-C4X-1101157)
- Linagliptin Impurity 52 (CAS 2463617-43-6)
- Linagliptin Impurity 7 (CAS 1446263-38-2)
Recommended Standards
- ((3AS,4R,6S,7R,7aS)-7-(benzoyloxy)-6-(ethylthio)-2,2-dimethyltetrahydro-4H-[1,3]dioxolo[4,5-c]pyran-4-yl)methyl benzoate (CAS 210093-48-4)
- (S)-N-(2-(1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-3-oxoisoindolin-4-yl)cyclopropanecarboxamide (CAS 340019-69-4)
- Liglitide Form B (CAS CATO-C4X-1101158)
- Biscarbofuran Sulfide (CAS 50673-14-8)
- Difelikefalin Impurity 49 (CAS CATO-C4X-304149)
- Glimepiride Impurity 24 (CAS 138428-37-2)
- Clofazimine EP Impurity A (CAS 102262-55-5)
- N,N-Diethylhydroxylamine (CAS 3710-84-7)
- (R)-2-Amino-2-(2-bromo-4-fluorophenyl)acetic acid hydrochloride (CAS 2177265-07-3)
- Diethyl (E)-2-((2-cyanovinyl)amino)malonate (CAS 1021175-71-2)
- Empagliflozin Impurity 240 (CAS CATO-C4X-1065240)
- 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-imidazole (CAS 1203671-64-0)
- 1-(1-(Furan-2-yl)ethylidene)-2-(2,4,6-trichlorophenyl)hydrazine (CAS 926386-92-7)
- Neuropeptide SF (human) (CAS 192387-39-6)
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