Clofazimine EP Impurity A CAS 102262-55-5
| CAS No. | 102262-55-5 |
| Molecular Formula | C24H16Cl2N4 |
| Molecular Weight | 431.32 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Clofazimine EP Impurity A (CAS 102262-55-5) is a certified pharmaceutical impurity reference standard with the molecular formula C24H16Cl2N4 and a molecular weight of 431.32 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution, Clofazimine EP Impurity A is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 431.32 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C24H16Cl2N4 |
| Molecular Weight | 431.32 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 18.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Clofazimine Standards
- Clofazimine Impurity 26 (CAS CATO-C4X-207126)
- Clofazimine Impurity 28 (CAS CATO-C4X-207128)
- Clofazimine Impurity 29 (CAS CATO-C4X-207129)
- Clofazimine Impurity 9 (CAS 96762-04-8)
- Clofazimine Impurity 3 (CAS 90712-89-3)
- Clofazimine Impurity 14 (CAS CATO-C4X-207114)
- Clofazimine Impurity 17 (CAS CATO-C4X-207117)
- Clofazimine Impurity 2 (CAS 2158184-11-1)
Recommended Standards
- (((5-(5-Oxo-4,5-dihydroisoxazol-3-yl)furan-2-yl)phosphoryl)bis(oxy))bis(methylene) bis(2-methylpropanoate) (CAS 1243184-62-4)
- Tert-butyl 4-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)carbamoyl)piperazine-1-carboxylate (CAS 1704068-57-4)
- Tofacitinib Impurity 211 (CAS CATO-C4X-1079211)
- Tert-butyl 4-((3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)carbamoyl)piperazine-1-carboxylate (CAS 1704081-91-3)
- Cefcapene Impurity 94 (CAS CATO-C4X-182494)
- Esomeprazole impurity 126 (CAS CATO-C4X-1112126)
- Alanyl Glutamine Impurity 25 TFA Salt (CAS CATO-C4X-197425)
- Cefamandole Impurity 13 (CAS CATO-C4X-122113)
- Desoximetasone EP Impurity H (CAS 52092-65-6)
- 3-(3-Chloro-1H-1,2,4-triazol-5-yl)pyridine (CAS 1215295-94-5)
- 5-Isopropyl-1,2,3-thiadiazole-4-carboxylic acid (CAS 1445950-78-6)
- 3,3-Dichloro-1-methylindolin-2-one (CAS 114380-33-5)
- 3-(Aminomethyl)-1-[(tert-Butoxy)carbonyl]azetidine-3-carboxylic acid hydrochloride (CAS 1788041-46-2)
- Glucagon (1-29) (CAS 16941-32-5)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com