N-{[3-(4-chlorophenyl)-1,2-oxazol-5-yl]methyl}-2,2,2-trifluoroacetamide CAS 672951-48-3

Purity 97%+In StockPharmaceutical Standards
CAS No.672951-48-3
Molecular FormulaC12H8ClF3N2O2
Molecular Weight304.65 g/mol
CategoryPharmaceutical Standards / API Standards
AvailabilityIn Stock

Chemical Structure

N-{[3-(4-chlorophenyl)-1,2-oxazol-5-yl]methyl}-2,2,2-trifluoroacetamide CAS 672951-48-3 chemical structure

Description

N-{[3-(4-chlorophenyl)-1,2-oxazol-5-yl]methyl}-2,2,2-trifluoroacetamide (C12H8ClF3N2O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).

N-{[3-(4-chlorophenyl)-1,2-oxazol-5-yl]methyl}-2,2,2-trifluoroacetamide (CAS 672951-48-3), molecular formula C12H8ClF3N2O2 and molecular weight 304.65 g/mol, is a CATO reference standard with documented purity and traceability.

Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

Molecular FormulaC12H8ClF3N2O2
Molecular Weight304.65 g/mol
AppearancePale yellow to yellow crystalline powder. (slight halide-like odor, low volatility)
Purity97%+
StorageStore at 2-8°C, protect from light, keep sealed and dry
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions
Degree of Unsaturation (DBE)8.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1985
Halogen ContentF/Cl-containing
Nitrogen Atoms2

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