(2-Chloro-4-fluorophenyl)acetyl chloride CAS 676348-45-1
| CAS No. | 676348-45-1 |
| Molecular Formula | C8H5Cl2FO |
| Molecular Weight | 207.03 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
(2-Chloro-4-fluorophenyl)acetyl chloride (CAS 676348-45-1) is a high-purity analytical reference standard with the molecular formula C8H5Cl2FO and a molecular weight of 207.03 g/mol.
Based on its molecular formula C8H5Cl2FO, (2-Chloro-4-fluorophenyl)acetyl chloride contains a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 207.03 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), (2-Chloro-4-fluorophenyl)acetyl chloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H5Cl2FO |
| Molecular Weight | 207.03 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
- 2-(3-Chloro-2-fluorophenyl)acetyl chloride (CAS 1040861-09-3)
- 2-Chloro-4-fluoro-3-methylbenzoyl chloride (CAS 1058721-62-2)
- 4-Chloro-2-fluorophenylacetyl chloride (CAS 1159797-03-1)
- 2-Chloro-1-(2-chloro-4-fluorophenyl)ethan-1-one (CAS 1160101-71-2)
- 2-Chloro-5-fluorophenylacetyl chloride (CAS 1175028-47-3)
- 2-Chloro-1-(3-chloro-5-fluorophenyl)ethan-1-one (CAS 1214323-02-0)
- 2-Chloro-1-(2-chloro-5-fluorophenyl)ethan-1-one (CAS 1214391-59-9)
- 2-Chloro-6-fluorophenylacetyl chloride (CAS 179314-61-5)
Recommended Standards
- (2,4-Dimethyl-6-propionylpyridin-3-yl)boronic acid (CAS 2862000-94-8)
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- (2-(Propylcarbamoyl)phenyl)boronic acid (CAS 874459-87-7)
- (3-(Isopropylcarbamoyl)phenyl)boronic acid (CAS 397843-69-5)
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- 7-Chloro-N-(2-fluorobenzyl)quinazolin-4-amine (CAS 477861-80-6)
- 1-[2,6-Dinitro-4-(trifluoromethyl)phenyl]-1,4-diazepane (CAS 341967-79-1)
- 2-(Aminomethyl)-4-(cyclopropylmethoxy)phenol (CAS 1243381-71-6)
- 3-Hydroxy-4-methylquinolin-2(1H)-one (CAS 24186-98-9)
- H-Cys(NPys)-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-NH2 trifluoroacetate salt (CAS 1676104-79-2)
- 1-Cyclohexyl-N,N'-diethyl-1-methylsilanediamine (CAS 1352486-81-7)
- (3-Bromo-4-nitrophenoxy)(tert-butyl)dimethylsilane (CAS 1475468-02-0)
- TRAF6 Control Peptide trifluoroacetate salt (CAS 852690-80-3)
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