2-Chloro-5-fluorophenylacetyl chloride CAS 1175028-47-3
| CAS No. | 1175028-47-3 |
| Molecular Formula | C8H5Cl2FO |
| Molecular Weight | 207.03 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 2-Chloro-5-fluorophenylacetyl chloride is closely related to a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies 2-Chloro-5-fluorophenylacetyl chloride (CAS 1175028-47-3), a certified reference material (molecular formula C8H5Cl2FO, MW 207.03 g/mol) for analytical method development and quality control.
The molecular framework of 2-Chloro-5-fluorophenylacetyl chloride (C8H5Cl2FO) is characterized by a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 2-Chloro-5-fluorophenylacetyl chloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H5Cl2FO |
| Molecular Weight | 207.03 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
- 2-(3-Chloro-2-fluorophenyl)acetyl chloride (CAS 1040861-09-3)
- 2-Chloro-4-fluoro-3-methylbenzoyl chloride (CAS 1058721-62-2)
- 4-Chloro-2-fluorophenylacetyl chloride (CAS 1159797-03-1)
- 2-Chloro-1-(2-chloro-4-fluorophenyl)ethan-1-one (CAS 1160101-71-2)
- 2-Chloro-1-(3-chloro-5-fluorophenyl)ethan-1-one (CAS 1214323-02-0)
- 2-Chloro-1-(2-chloro-5-fluorophenyl)ethan-1-one (CAS 1214391-59-9)
- 2-Chloro-6-fluorophenylacetyl chloride (CAS 179314-61-5)
- (2-Chloro-4-fluorophenyl)acetyl chloride (CAS 676348-45-1)
Recommended Standards
- 2-(2,4-Dichloro-5-fluorophenyl)oxirane (CAS 1179042-36-4)
- 1,2,3,7,8,9-Hexachloro[13C12]dibenzo-p-dioxinDiscontinued (CAS 109719-82-6)
- 6-(bromomethyl)-1,2,3,4-tetrahydropyrimidine-2,4-dione (CAS 126401-89-6)
- 2,2-Dichloro-1-(3-Fluorophenyl)Ethanone (CAS 127728-55-6)
- 6-Bromo-2,3-dihydrobenzo[b][1,4]dioxine-5-carbaldehyde (CAS 249636-65-5)
- 1-Methylspiro[indoline-3,2'-pyran]-2,6'(3'H)-dione (CAS 882041-46-5)
- Isomaltoheptaose (CAS 6513-12-8)
- 2-Chloro-6-ethoxy-4-formylphenyl 2-chlorobenzoate (CAS 431931-40-7)
- Ethyl 2-(2-chloro-6-fluoropyridin-4-yl)acetate (CAS 1807169-92-1)
- 5-(4-Chlorophenyl)-2-[3-(trifluoromethyl)phenoxy]pyridine-3-carbonitrile (CAS 338955-27-4)
- 5,6-Dichloro-[2,3'-bipyridine]-3-carbonitrile (CAS 1774900-99-0)
- 6-Nitrochrysene-d11 (CAS 203805-92-9)
- 1-Bromo-4-chloro-2-nitro-5-(trifluoromethyl)benzene (CAS 863111-47-1)
- Semaglutide Impurity 177 (CAS CATO-C4X-2226177)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com