Clotrimazole Impurity 29 CAS 103855-36-3
| CAS No. | 103855-36-3 |
| Molecular Formula | C19H14Cl2O |
| Molecular Weight | 329.22 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Clotrimazole Impurity 29 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Clotrimazole Impurity 29 (CAS 103855-36-3, C19H14Cl2O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a steroid core, a hydroxyl group, an ether linkage, chlorine substitution, Clotrimazole Impurity 29 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 329.22 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C19H14Cl2O |
| Molecular Weight | 329.22 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | Cl-containing |
Related Clotrimazole Standards
- Clotrimazole Impurity 9 (CAS 23593-68-2)
- Clotrimazole Impurity 18 (CAS 717109-43-8)
- Clotrimazole TRAM-34 Impurity (CAS 289905-88-0)
- Clotrimazole Impurity 19 (CAS 23593-76-2)
- Clotrimazole EP Impurity B (CAS 23593-71-7)
- Clotrimazole (CAS 23593-75-1)
- Clotrimazole Impurity 20 (CAS 27023-37-6)
- Clotrimazole Impurity 22 (CAS 59154-29-9)
Recommended Standards
- N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)thiophene-2-carboxamide (CAS 2246652-82-2)
- Tepotinib impurity 28 (CAS CATO-C4X-337428)
- Ethyl 5-(bis(2-chloroethyl)amino)-1H-indole-3-carboxylate (CAS 92869-57-3)
- Fenoxanil (CAS 115852-48-7)
- Asparagine EP Impurity G (CAS CATO-C4X-24423)
- Vericiguat Impurity 93 (CAS CATO-C4X-289693)
- Formoterol impurity 122 (CAS 143687-25-6)
- 1-(5-Methylpyridin-3-yl)cyclopropan-1-ol (CAS 1488665-71-9)
- 6-Amino-1-methyl-1H-indole-3-carboxylic acid (CAS 1058740-80-9)
- (S)-3-((5-Amino-1-methoxy-1,5-dioxopentan-2-yl)amino)propaneselenoic O-acid (CAS 26046-89-9)
- 2-(2-Bromophenyl)-1-phenylethanone (CAS 16897-97-5)
- N-(3-(6-Oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl)acetamide (CAS 14714-33-1)
- (2S)-2-Amino-3-ethoxypropan-1-ol (CAS 58577-92-7)
- D-allo-Thr7-Semaglutide (CAS CATO-C4X-2226242)
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