Brivudine Impurity N2 CAS 69304-49-0
| CAS No. | 69304-49-0 |
| Molecular Formula | C6H5BrN2O2 |
| Molecular Weight | 217.02 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Brivudine Impurity N2 (CAS 69304-49-0) is a certified pharmaceutical impurity reference standard with the molecular formula C6H5BrN2O2 and a molecular weight of 217.02 g/mol.
The molecular framework of Brivudine Impurity N2 (C6H5BrN2O2) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, bromine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H5BrN2O2 |
| Molecular Weight | 217.02 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1976 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 2 |
Related Brivudine Standards
- Brivudine Impurity 2 (CAS 765235-25-4)
- Brivudine Impurity 3 (CAS CATO-C4X-27583)
- Brivudine Impurity 4 (CAS CATO-C4X-27584)
- Brivudine Impurity 10 (CAS 55520-67-7)
- Brivudine Impurity 12 (CAS 144301-84-8)
- Brivudine Impurity 13 (CAS 144301-85-9)
- Brivudine Impurity C17 (CAS 74131-08-1)
- Brivudine Impurity 15 (CAS 113890-35-0)
Recommended Standards
- 7-Bromobenzo[d][1,3]dioxol-5-ol (CAS 66799-94-8)
- Crisaborole Impurity 6 (CAS 28547-28-6)
- 6-Bromobenzo[d][1,3]dioxol-5-ol (CAS 6941-70-4)
- Methyl 3-Bromo-2-pyrazinecarboxylate (CAS 51171-02-9)
- Dexmedetomidine Impurity 10 (CAS 944263-08-5)
- Tegoprazan impurity 50 (CAS 3007659-89-1)
- Dotinurad Impurity 177 (CAS CATO-C4X-2494177)
- 7-Bromo-3-hydroxybenzo[b]thiophene-2-carboxylic acid (CAS 1784121-77-2)
- 5-Chloro-6-isopropyl-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbaldehyde (CAS 2573901-15-0)
- 1-[2-(2-methylphenyl)-1,3-thiazole-4-sulfonyl]piperazine (CAS 1311315-66-8)
- (S)-2-(4-fluoro-3-(trifluoromethyl)phenyl)pyrrolidine (CAS 1213462-40-8)
- 1,2,3-Thiadiazole-5-thiol (CAS 69893-92-1)
- (1R,4R)-rel-tert-Butyl 2,5-diazabicyclo[2.2.1]heptane-2-carboxylate (CAS 1217975-73-9)
- [Tyr15] Fibrinopeptide B, human (CAS 125455-56-3)
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