Dextromethorphan Impurity N1 CAS 69376-27-8
| CAS No. | 69376-27-8 |
| Molecular Formula | C17H23NO |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Dextromethorphan Impurity N1 (CAS 69376-27-8), a pharmacopoeial impurity reference standard (molecular formula C17H23NOHCl, MW 293.83 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Dextromethorphan Impurity N1 (C17H23NOHCl) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 6.0, corresponding to approximately 6 ring(s) or double-bond equivalent(s). With a molecular weight of 293.83 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C17H23NO HCl |
| Molecular Weight | 293.83 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1976 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Dextromethorphan Standards
- Dextromethorphan impurity 41 (CAS 1058187-40-8)
- Dextromethorphan EP Impurity A Hydrochloride (CAS 1087-69-0)
- Dextromethorphan N-Oxide（HCl） (CAS 1177419-85-0)
- Dextromethorphan N-Oxide (CAS 1177494-18-6)
- Dextromethorphan Impurity 3-methoxy-17-methyl-morphinan-10β-ol Formic acid (CAS 120442-81-1（free base）)
- Dextromethorphan (CAS 125-69-9)
- Dextromethorphan impurity 23 (CAS 125-70-2)
- Dextromethorphan EP Impurity B (CAS 125-73-5)
Recommended Standards
- Zolpidem EP Impurity D (CAS 836627-56-6)
- Baxdrostat Impurity 16 (CAS 3060412-71-4)
- CAS 62780-92-1 (CAS 62780-92-1)
- (2E)-1-(4-Aminophenyl)-3-(2-methoxyphenyl)prop-2-en-1-one (CAS 807642-52-0)
- N-(Benzo[d][1,3]dioxol-5-yl)-2-((4-(4-bromophenyl)-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)acetamide (CAS 477331-28-5)
- Tetrahydro-2H-thiopyran-3-carbonitrile (CAS 1493910-99-8)
- 1-(2-(Difluoromethoxy)benzo[d]oxazol-4-yl)ethanone (CAS 1804191-75-0)
- N-Desmethyl Almotriptan-d3 (CAS 1346604-71-4)
- 1-(3,4-Dihydroquinolin-1(2H)-yl)-2-(thieno[2,3-d]pyrimidin-4-yloxy)ethan-1-one (CAS 742113-71-9)
- Neuropeptide K (human, porcine, rat) trifluoroacetate salt (CAS 96827-05-3)
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