Flunarizine EP Impurity D（(Z)-Flunarizine） CAS 693765-11-6
| CAS No. | 693765-11-6 |
| Molecular Formula | C26H26F2N2 |
| Molecular Weight | 404.49 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Flunarizine EP Impurity D（(Z)-Flunarizine） (CAS 693765-11-6) is a certified pharmaceutical impurity reference standard with the molecular formula C26H26F2N2 and a molecular weight of 404.49 g/mol.
The molecular framework of Flunarizine EP Impurity D（(Z)-Flunarizine） (C26H26F2N2) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C26H26F2N2 |
| Molecular Weight | 404.49 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Flunarizine Standards
- Flunarizine EP Impurity C (CAS 90830-31-2)
- Flunarizine (CAS 52468-60-7)
- Flunarizine impurity 39 (CAS 19422-37-8)
- Flunarizine Impurity 6 (CAS 768360-45-8)
- Flunarizine impurity 34 (CAS CATO-C4X-135734)
- Flunarizine Impurity 7 (CAS 87166-81-2)
- Flunarizine Impurity N1 (CAS 123375-94-0)
- Flunarizine impurity 53 (CAS CATO-C4X-135753)
Recommended Standards
- Tert-butyl 4-(6-((5-formylthiazol-2-yl)amino)-2-methylpyrimidin-4-yl)piperazine-1-carboxylate (CAS 936845-85-1)
- (1S,7R,8R,8aR)-8-(2-((2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-7-methyl-6-oxo-1,2,6,7,8 (CAS 1114834-76-2)
- N-{1-[(2,4-Difluorophenyl)Amino]-1-Oxo-2-Propanyl}-3,5,7-Trimethyl-1-Adamantanecarboxamide (CAS 403695-20-5)
- tert-Butyl 3-((4-(morpholine-4-carbonyl)phenoxy)methyl)piperidine-1-carboxylate (CAS 1146080-07-0)
- Neostigmine impurity 40 (CAS CATO-C4X-204240)
- Upadacitinib Impurity 65 (CAS 2460133-49-5)
- Apixaban Impurity 88 (CAS CATO-C4X-108888)
- 3-Chloro-5-fluoro-2-hydroxy-benzoic acid (CAS 4068-62-6)
- 5-((3-(4-(Allyloxy)phenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)-3-(4-methylbenzyl)-2-thioxothiazolidin-4-one (CAS 623933-21-1)
- 4-[(Cyclopentylmethoxy)methyl]piperidinehydrochloride (CAS 1185299-09-5)
- Cefixime Impurity 86 (CAS CATO-C4X-113986)
- (2-((1,4-Dioxa-8-azaspiro[4.5]Decan-8-yl)methyl)phenyl)(2-fluorophenyl)methanone (CAS 898756-24-6)
- 2-Amino-6-methyl-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-5-one (CAS 1092281-08-7)
- Semaglutide impurity 25 (CAS CATO-C4X-222625)
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