Rilpivirine HCl CAS 700361-47-3
| CAS No. | 700361-47-3 |
| Molecular Formula | C22H18N6 |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 402.89 g/mol gives Rilpivirine HCl distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Rilpivirine HCl (CAS 700361-47-3) is a high-purity analytical reference standard with the molecular formula C22H18N6HCl and a molecular weight of 402.89 g/mol.
The molecular framework of Rilpivirine HCl (C22H18N6HCl) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H18N6 HCl |
| Molecular Weight | 402.89 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 6 |
Related Rilpivirine Standards
- Rilpivirine Impurity 6 (CAS 1009330-41-9)
- Rilpivirine-d6 (CAS 1312424-26-2)
- Rilpivirine N-Glucuronide (CAS 1437791-52-0)
- Rilpivirine Impurity 12 (CAS 1446439-51-5)
- (Z)-Rilpivirine Hydrochloride (CAS 1502822-82-3)
- Rilpivirine Impurity 4 (CAS 1629023-90-0)
- Rilpivirine Keto Impurity (CAS 189956-45-4)
- Rilpivirine Chloro Impurity (CAS 244768-32-9)
Recommended Standards
- 10,11,12,13-Tetrahydro-5-phenoxydiindeno[7,1-de:1′,7′-fg][1,3,2]dioxaphosphocin (CAS 1119754-16-3)
- 5-(M-tolyl)piperidine-3-carboxamide (CAS 1421601-08-2)
- 4,5-dichloropyridazin-3-amine (CAS 1351000-23-1)
- N-Boc-N-methyl-(S)-2-allylglycine (CAS 136092-76-7)
- 2,3-Dihydro-1H-pyrrolo[3,4-c]pyridine Hydrochloride (CAS 651558-58-6)
- 4-(3-Bromophenyl)-4-oxobutanoic acid (CAS 62903-13-3)
- tert-Butyl diisopropylcarbamate (CAS 105678-27-1)
- Chlorthiophos I (CAS 21923-23-9)
- 5-(3-Chloro-4-fluorophenyl)-5-methyl-2,4-imidazolidinedione (CAS 1152850-20-8)
- Semaglutide impurity 200 (CAS CATO-C4X-2226200)
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