Bedaquiline impurity 44 CAS 93499-67-3
| CAS No. | 93499-67-3 |
| Molecular Formula | C9H7NO2 |
| Molecular Weight | 161.16 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Bedaquiline impurity 44 (C9H7NO2) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a process- or degradation-related impurity, Bedaquiline impurity 44 (CAS 93499-67-3, C9H7NO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H7NO2 |
| Molecular Weight | 161.16 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1983 |
| Nitrogen Atoms | 1 |
Related Bedaquiline Standards
- Bedaquiline impurity 39 (CAS 72543-44-3)
- Bedaquiline Impurity 9 (CAS 22422-69-1)
- Bedaquiline impurity 43 (CAS 90724-56-4)
- Bedaquiline Impurity 16 (CAS CATO-C4X-116716)
- Bedaquiline Impurity 17 (CAS CATO-C4X-116717)
- Bedaquiline Impurity 67 (CAS 345949-37-3)
- Bedaquiline impurity 40 (CAS 848694-09-7)
- Bedaquiline impurity 41 (CAS 860720-24-7)
Recommended Standards
- Adefovir Impurity 12 (CAS 20245-85-6)
- Tropisetron Hydrochloride EP Impurity B (CAS 771-50-6)
- Brexpiprazole Impurity 4 (CAS 70500-72-0)
- Ramosetron Impurity 10 (CAS 2058-74-4)
- N-nitroso Amlodipine Impurity 149 (CAS CATO-C4X-1095149)
- Pidotimod Impurity 27 (CAS CATO-C4X-107827)
- Imrecoxib Impurity 74 (CAS CATO-C4X-237974)
- 6-[4-(Trifluoromethoxy)phenyl]-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine (CAS 1262618-39-2)
- Belumosudil Impurity 17 HCl (CAS 97454-48-3(free base))
- 5-Fluoro-2-(1H-imidazol-4-yl)pyridine (CAS 758679-59-3)
- 1-(4-(Trifluoromethyl)phenyl)azetidin-3-amine (CAS 1342753-23-4)
- 4,4-Dimethylspiro[2.5]octan-6-one (CAS 2760537-54-8)
- 2-Imino-2H-pyrido[1,2-a]pyrimidin-4(3H)-one (CAS 536719-83-2)
- Semaglutide impurity 276 (CAS CATO-C4X-2226276)
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