Ethyl 8-chloroquinoline-3-carboxylate CAS 71083-19-7
| CAS No. | 71083-19-7 |
| Molecular Formula | C12H10ClNO2 |
| Molecular Weight | 235.67 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Ethyl 8-chloroquinoline-3-carboxylate (CAS 71083-19-7), molecular formula C12H10ClNO2 and molecular weight 235.67 g/mol, is a CATO reference standard with documented purity and traceability.
Ethyl 8-chloroquinoline-3-carboxylate (C12H10ClNO2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H10ClNO2 |
| Molecular Weight | 235.67 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1977 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Ethyl Standards
- Ethyl 7-chloroquinoline-2-carboxylate (CAS 116529-90-9)
- Ethyl 5-chloroquinoline-4-carboxylate (CAS 116557-07-4)
- Ethyl 7-Chloroquinoline-3-carboxylate (CAS 133455-49-9)
- Ethyl 4-Chloroquinoline-3-carboxylate (CAS 13720-94-0)
- ethyl 3-chloroquinoline-6-carboxylate (CAS 1378260-98-0)
- Ethyl 4-chloroquinoline-6-carboxylate (CAS 148018-34-2)
- Ethyl 2-Chloroquinoline-3-carboxylate (CAS 16498-86-5)
- Ethyl 5-chloroquinoline-6-carboxylate (CAS 180421-62-9)
Recommended Standards
- Ethyl 8-chloro-6-quinolinecarboxylate (CAS 916812-09-4)
- Methyl 1-chloro-3-methylisoquinoline-6-carboxylate (CAS 2092314-49-1)
- ethyl 7-chloroquinoline-6-carboxylate (CAS 916812-04-9)
- Methyl 1-chloro-4-methylisoquinoline-3-carboxylate (CAS 89928-78-9)
- 3,4-Dimethyl[1,1-biphenyl]-3-amine (CAS 728919-24-2)
- 2-(5-Amino-2-methoxyphenoxy)acetamide (CAS 954562-31-3)
- Benzaldehyde-α-<SUP>13</SUP>C,d<SUB>6</SUB> (CAS 1215830-20-8)
- 1-(5,6,7,8-Tetrahydroimidazo[1,2-a]pyridin-2-yl)prop-2-en-1-one (CAS 1999574-83-2)
- 5-(Trifluoromethyl)-6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-2-carboxylic acid (CAS 2413408-01-0)
- 4'-(Methylsulfonyl)-[1,1'-biphenyl]-2-amine (CAS 139768-67-5)
- tert-Butyl 4-(iodomethyl)benzylcarbamate (CAS 218796-73-7)
- Isoquinoline-1,3-diamine (CAS 1955-65-3)
- Acetophenone impurity 14 (CAS CATO-C4X-260814)
- Myosin Kinase Inhibiting Peptide (CAS 119386-39-9)
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