4-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)oxy)aniline CAS 71422-80-5
| CAS No. | 71422-80-5 |
| Molecular Formula | C12H8ClF3N2O |
| Molecular Weight | 288.65 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
4-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)oxy)aniline (CAS 71422-80-5) is a high-purity analytical reference standard with the molecular formula C12H8ClF3N2O and a molecular weight of 288.65 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, 4-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)oxy)aniline is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 288.65 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 4-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)oxy)aniline meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H8ClF3N2O |
| Molecular Weight | 288.65 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1977 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
- 1-Acetyl-4-chloro-3-phenyl-5-(trifluoromethyl)-1H-pyrazole (CAS 1017793-56-4)
- 3-Chloro-4-((3-(trifluoromethyl)pyridin-2-yl)oxy)aniline (CAS 1099669-15-4)
- 5-Chloro-3-(trifluoromethyl)-1-p-tolyl-1H-pyrazole-4-carbaldehyde (CAS 1152978-14-7)
- 3-Chloro-4-((6-(trifluoromethyl)pyridin-2-yl)oxy)aniline (CAS 1211669-81-6)
- 4-Chloro-3'-(trifluoromethoxy)-[1,1'-biphenyl]-3-ol (CAS 1261512-80-4)
- 4-Chloro-4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-ol (CAS 1261723-86-7)
- 1-(4-Chloro-5-phenyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)ethan-1-one (CAS 231947-23-2)
- 2-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)oxy)aniline (CAS 98968-77-5)
Recommended Standards
- 3-Chloro-6-(4-methoxyphenyl)-4-(trifluoromethyl)pyridazine (CAS 2060062-38-4)
- 4-((6-Chloro-4-(trifluoromethyl)pyridin-2-yl)oxy)aniline (CAS 86575-23-7)
- 3-Chloro-6-(3-methoxyphenyl)-4-(trifluoromethyl)pyridazine (CAS 2059994-09-9)
- 4-Chloro-5-methoxy-2-[3-(trifluoromethyl)phenyl]pyrimidine (CAS 478030-28-3)
- N-methyl-N-(tetrahydro-2H-pyran-4-yl)piperidin-4-amine hydrochloride (CAS 1451391-78-8)
- Decanedioic acid, polymer with 2,2'-oxybis[ethanol] (CAS 25610-21-3)
- 2-cyclopropyl-5-hydrazinyl-1H-1,3-benzodiazole (CAS 1903252-26-5)
- 2-(2,6-Diisopropylphenyl)-5-nitroisoindoline-1,3-dione (CAS 100823-00-5)
- 8-Chloro-[1,2,4]triazolo[4,3-b]pyridazin-7-amine (CAS 89284-31-1)
- (4-Chlorophenyl)(3-methylpiperazin-1-yl)methanone hydrochloride (CAS 1568455-19-5)
- Fenofibrate Impurity 7 (CAS 61002-52-6)
- Fluticasone Impurity 35 (CAS CATO-C4X-165035)
- 3-Methyl-1-[1-(4-methyl-1,3-thiazol-2-yl)ethyl]-2,5-dihydro-1H-pyrrole-2,5-dione (CAS 1341305-75-6)
- Peptide Impurity 64 (CAS CATO-CPTD788964)
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