Indometacin Impurity 30 CAS 72155-33-0
| CAS No. | 72155-33-0 |
| Molecular Formula | C22H22ClNO6 |
| Molecular Weight | 431.87 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Indometacin Impurity 30 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Indometacin Impurity 30 (CAS 72155-33-0, C22H22ClNO6) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Indometacin Impurity 30 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 431.87 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C22H22ClNO6 |
| Molecular Weight | 431.87 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >85% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1977 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Indometacin Standards
- Indometacin Impurity 21 (CAS 71848-87-8)
- Indometacin Impurity 56 (CAS CATO-C4X-147056)
- Indometacin Impurity 22 (CAS 78458-34-1)
- Indometacin Impurity 23 (CAS CATO-C4X-147023)
- Indometacin Impurity 31 (CAS CATO-C4X-147031)
- Indometacin Impurity 32 (CAS CATO-C4X-147032)
- Indometacin Impurity 33 (CAS CATO-C4X-147033)
- Indometacin Impurity 34 (CAS CATO-C4X-147034)
Recommended Standards
- Darolutamide Impurity 17 (CAS CATO-C4X-310617)
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- Ochratoxin C (CAS 4865-85-4)
- 6-Amino-4-[[3-chloro-4-(2-pyridyloxy)phenyl]amino]-7-ethoxyquinoline-3-carbonitrile (CAS 1956340-48-9)
- Oclacitinib Impurity 24 (CAS CATO-C4X-301824)
- Betamethasone Impurity 40 (CAS 1815577-58-2（free base）)
- Pimobendan Impurity 15-d3 (CAS CATO-C4X-246116)
- 2-(Dimethylamino)-4-propylpyrimidine-5-carboxylic acid (CAS 180283-74-3)
- 6-Bromo-2,3,4,9-tetrahydro-1h-pyrido[3,4-b]indole-1-carboxylic acid (CAS 24335-16-8)
- 2,7-Diazaspiro[4.4]nonane Dihydrochloride (CAS 1394122-72-5)
- 1,3-Diazaspiro[4.7]Dodecane-2,4-dione (CAS 710-94-1)
- 4-Bromo-2-(1H-imidazol-2-yl)phenol (CAS 289506-17-8)
- Niraparib Impurity 68 (CAS CATO-C4X-232968)
- Sperm Activating Peptide, Sea Urchin (CAS 140653-27-6)
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