Metoclopramide Hydrochloride CAS 7232-21-5
| CAS No. | 7232-21-5 |
| Molecular Formula | C14H22ClN3O2 |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Metoclopramide Hydrochloride (CAS 7232-21-5), molecular formula C14H22ClN3O2HCl and molecular weight 336.26 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Metoclopramide Hydrochloride is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 336.26 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H22ClN3O2 HCl |
| Molecular Weight | 336.26 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1959 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Metoclopramide Standards
- Metoclopramide EP Impurity E (CAS 100-36-7)
- Metoclopramide Impurity 68 (CAS 101385-94-8)
- Metoclopramide impurity 70 (CAS 102313-35-9)
- Metoclopramide Impurity 11 (CAS 111049-74-2)
- Metoclopramide-related Impurity (CAS 121048-67-7)
- Metoclopramide-d3 (CAS 1216522-89-2)
- Metoclopramide impurity 60 (CAS 1242047-97-7)
- Metoclopramide Impurity 83 (CAS 1242047-99-9)
Recommended Standards
- (S)-1-(3-Amino-pyridin-2-yl)-ethylamine Hydrochloride 1798816-74-6 (CAS 1798816-74-6)
- 5-Bromo-6-methyl-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile (CAS 1260383-92-3)
- [(2E)-3-phenylprop-2-en-1-yl](prop-2-en-1-yl)amine (CAS 86386-72-3)
- N-(4-Methyl-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)acetamide (CAS 71521-92-1)
- 1-|A-D-Glucopyranuronosyl-3-[1-hydroxy-4-(methylnitrosoamino)butyl]pyridinium Inner Salt 350508-29-1 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol N-|A-D-Glucuronide NNAL-N-|A-D-Glucuronide (CAS 350508-29-1)
- 2-Amino-N-(1-phenylpropyl)acetamide (CAS 1251320-30-5)
- 3-(Dimethylamino)-1-phenyl-2,3-dihydroquinazolin-4(1H)-one (CAS 90071-01-5)
- 1-Ethyl-4-hydroxypyridin-2(1H)-one (CAS 1779935-63-5)
- 2-Chlorobenzene-1-sulfinyl chloride (CAS 1852086-12-4)
- [Formaldehyde Schiff-base]-Semaglutide Impurity 136 X TFA Salt (CAS CATO-C4X-2226136)
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