Sitagliptin Impurity 62 CAS 723286-98-4
| CAS No. | 723286-98-4 |
| Molecular Formula | C4H2ClF3N2O |
| Molecular Weight | 186.52 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 186.52 g/mol gives Sitagliptin Impurity 62 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Sitagliptin Impurity 62 (CAS 723286-98-4, C4H2ClF3N2O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Sitagliptin Impurity 62 (C4H2ClF3N2O) contains an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C4H2ClF3N2O |
| Molecular Weight | 186.52 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Sitagliptin Standards
- Sitagliptin Impurity 80 (CAS 220199-85-9)
- Sitagliptin Impurity 107 (CAS 89124-06-1)
- Sitagliptin Impurity 60 (CAS 1305324-02-0)
- Sitagliptin Impurity 63 (CAS 1864680-46-5)
- Sitagliptin Impurity 111 (CAS 1335952-08-3)
- Sitagliptin Impurity 122 (CAS CATO-C4X-1144122)
- Sitagliptin Impurity N31 (CAS 910409-20-0)
- Sitagliptin Impurity 76 (CAS 209995-38-0)
Recommended Standards
- 3-(Chloromethyl)-5-(trifluoromethyl)-1,2,4-oxadiazole (CAS 890095-69-9)
- Methyl4-chloro-4,4-difluoroacetoacetate (CAS 117510-94-8)
- 5-Chloromethyl-3-trifluoromethyl-[1,2,4]oxadiazole (CAS 100442-49-7)
- 6-Chloro-4-nitronicotinaldehyde (CAS 1060809-78-0)
- Revefenacin Impurity 26 (CAS 108015-71-0)
- Fluocinolone Acetonide Impurity 46 (CAS CATO-C4X-238146)
- Azelastine impurity 56 (CAS CATO-C4X-139656)
- 4-Fluoro-3-methyl-2-oxo-2,3-dihydrobenzo[d]oxazole-7-sulfonyl chloride (CAS 2387597-35-3)
- 2-Hydroxy-2-(6-methoxynaphthalen-2-yl)acetonitrile (CAS 76635-90-0)
- N-(3-(dimethylamino)propyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-3-carboxamide dihydrochloride (CAS 1220038-01-6)
- Upadacitinib Impurity 93 (CAS CATO-C4X-240593)
- 2-[Benzyl(cyclopropylmethyl)amino]ethanol (CAS 1249321-20-7)
- 2-O-ethyl 1-O-methyl benzene-1,2-dicarboxylate 34006-77-4 (CAS 34006-77-4)
- Liraglutide Impurity 19 TFA Salt (CAS CATO-C4X-199219)
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