Sitagliptin Impurity 80 CAS 220199-85-9

Purity 97%+In StockPharmacopoeial Impurity Standards
CAS No.220199-85-9
Molecular FormulaC9H17NO3
Molecular Weight187.24 g/mol
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Sitagliptin Impurity 80 CAS 220199-85-9 chemical structure

Description

As a certified reference material (CRM), Sitagliptin Impurity 80 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

CATO supplies Sitagliptin Impurity 80 (CAS 220199-85-9), a pharmacopoeial impurity reference standard (molecular formula C9H17NO3, MW 187.24 g/mol) used for the identification and quantification of trace impurities in APIs.

The molecular framework of Sitagliptin Impurity 80 (C9H17NO3) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.

This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.

Physical & Chemical Properties

Molecular FormulaC9H17NO3
Molecular Weight187.24 g/mol
Purity97%+
StorageStore at 2-8°C, protect from light, keep sealed and dry
Solubility (reference)Soluble in methanol, ethanol, DMSO
StabilityLight-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening
Degree of Unsaturation (DBE)2.0
CAS Registry Year (est.)2019
Nitrogen Atoms1

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