8-Chloro-[1,3]dioxolo[4,5-g]quinazoline CAS 72700-23-3
| CAS No. | 72700-23-3 |
| Molecular Formula | C9H5ClN2O2 |
| Molecular Weight | 208.60 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
8-Chloro-[1,3]dioxolo[4,5-g]quinazoline (CAS 72700-23-3), molecular formula C9H5ClN2O2 and molecular weight 208.60 g/mol, is a CATO reference standard with documented purity and traceability.
8-Chloro-[1,3]dioxolo[4,5-g]quinazoline (C9H5ClN2O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), 8-Chloro-[1,3]dioxolo[4,5-g]quinazoline meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H5ClN2O2 |
| Molecular Weight | 208.60 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1977 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
- 3-Chloro-6-nitroquinoline (CAS 101860-71-3)
- 8-Chloro-1,7-naphthyridine-6-carboxylic acid (CAS 1019111-25-1)
- 3-(4-Chloro-3-nitrophenyl)prop-2-enenitrile (CAS 1027720-44-0)
- 3-Chloro-5-nitroisoquinoline (CAS 10296-47-6)
- 7-Chloro-4-nitroquinoline (CAS 1076199-85-3)
- 3-Chloro-5-nitroquinoline (CAS 116529-79-4)
- 6-chloro-3-nitro-pyridine-2-carboxylic acid (CAS 1204400-58-7)
- 8-Chloro-6-nitroquinoline (CAS 121465-04-1)
Recommended Standards
- 7-Chlorocinnoline-3-carboxylicacid (CAS 480451-01-2)
- 8-Chloro-4-oxo-4H-chromene-3-carbaldehyde (CAS 64481-09-0)
- 7-Chloro-8-nitroquinoline (CAS 71331-02-7)
- 8-chloro-5-nitro-quinoline (CAS 22539-55-5)
- 4-(Isopentyloxy)picolinimidamide hydrochloride (CAS 1179360-76-9)
- (4-Chloro-2-(difluoromethyl)phenyl)(pyridin-4-yl)methanone (CAS 1261734-20-6)
- 2-Fluoro-6-(hydroxymethyl)phenol (CAS 446-58-2)
- 2-amino-3H,4H-imidazo[2,1-f][1,2,4]triazin-4-one (CAS 1378585-36-4)
- Sodium 4-phenyl-1,3-thiazole-2-carboxylate (CAS 1246551-70-1)
- 2-Fluoro-4-nitro-1-(trifluoromethoxy)benzene (CAS 190902-95-5)
- Ammonium 3-oxo-3'-(phosphonooxy)-3H-spiro[iSobenzofuran-1,9'-xanthen]-6'-yl phosphate (CAS 197777-66-5)
- 3-(Trifluoromethyl)-1H-pyrazol-4-ol (CAS 1394955-16-8)
- 2-(5,6-Dimethylpyridin-3-yl)propan-2-ol (CAS 1862885-26-4)
- Neuropeptide S (rat) (CAS 412938-75-1)
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